Identifiers
HUGO:RPTOR
regulatory associated protein of MTOR, complex 1
HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122
HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / CORE 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / FATTY_ACID_BIOSYNTHESIS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / RCD_GENES 
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity   / IMMUNOSTIMULATORY_CORE_PATHWAYS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / PI3K_AKT_MTOR 

References
PMID:16469695 PMID:26159692 PMID:23087689
PMID:16469695, PMID:26159692
mTOR Complex 1 (mTORC1) is composed of mTOR itself, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8 (MLST8) and the recently identified PRAS40 and DEPTOR
 NATURAL_KILLER 
 DENDRITIC_CELL 
PMID:19864431
PMID:12150925
PMID:15755954

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / FATTY_ACID_BIOSYNTHESIS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / RCD_GENES 

References
rc_re370( Regulated Cell Death  ):
PMID:18439900
in HEK293
rc_re372( Regulated Cell Death  ):
logical:re372_s2093=FALSE

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / FATTY_ACID_BIOSYNTHESIS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / RCD_GENES 

References
rc_re370( Regulated Cell Death  ):
PMID:18439900
in HEK293
rc_re371( Regulated Cell Death  ):
influenceDelete: re to reactants
engagement of mTOR in mTORC1 does not titrate it out of mTORC2

References
s_akt1_re113:( Survival  ) PMID:21474067

1. RPTOR@Cytoplasm

1. RPTOR@Cytosol
2. RPTOR|​S722_pho|​S792_pho@Cytosol

1. (MLST8:​MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm
2. MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Cytoplasm
3. EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm
4. 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm
5. EIF3*:​EIF4A*:​EIF4B|​pho:​EIF4E*:​EIF4G*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PABP1*:​RPS6|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm

1. FKBP8:​RPTOR|​unk@Cytosol
2. DEPDC6:​RPTOR|​unk@Cytosol
3. 14-3-3*|​unk:​RPTOR|​S722_pho|​S792_pho@Cytosol
4. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@Cytosol
5. (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@Cytosol

1. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@INNATE_IMMUNE_CELL_Cytosol
2. (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@INNATE_IMMUNE_CELL_Cytosol

1. MLST8:​MTOR:​RPTOR@Lysosome
2. MLST8:​MTOR|​S2448_pho:​RPTOR@Lysosome
3. GDP:​GTP:​MLST8:​MTOR:​RPTOR:​Rag A/B*:​Rag C/D*@Lysosome

1. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
2. MLST8:​MTOR|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
3. MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
4. MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
5. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
6. DEPTOR:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
7. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome
8. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
9. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome

1. MLST8:​MTOR:​RPTOR|​unk@Nucleus
2. MLST8:​MTOR:​PPARGC1A:​RPTOR|​pho:​YY1@Nucleus

1. MLST8:​MTOR:​RPTOR|​unk@PML Body

1. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@T_cell
2. (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@T_cell

1. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@T_cell → (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@T_cell
2. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@Cytosol → (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@Cytosol
3. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@INNATE_IMMUNE_CELL_Cytosol → (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@INNATE_IMMUNE_CELL_Cytosol
4. Rag A/B*:​Rag C/D*@Cytosol + mo_s16 → GDP:​GTP:​MLST8:​MTOR:​RPTOR:​Rag A/B*:​Rag C/D*@Lysosome
5. GDP:​GTP:​MLST8:​MTOR:​RPTOR:​Rag A/B*:​Rag C/D*@Lysosome → GDP:​GTP:​Rag A/B*:​Rag C/D*@Lysosome + MLST8:​MTOR:​RPTOR@Lysosome
6. MLST8:​MTOR:​RPTOR@Lysosome → MLST8:​MTOR|​S2448_pho:​RPTOR@Lysosome
7. GDP:​GTP:​MLST8:​MTOR:​RPTOR:​Rag A/B*:​Rag C/D*@Lysosome → Cell cycle / survival / proliferation@Cytosol
8. DEPDC6@Cytosol + rc_s7967 → DEPDC6:​RPTOR|​unk@Cytosol
9. RPTOR@Cytosol → RPTOR|​S722_pho|​S792_pho@Cytosol
10. MLST8@Cytosol + MTOR@Cytosol + RPTOR@Cytosol → rc_s5670
11. 14-3-3*|​unk@Cytosol + RPTOR|​S722_pho|​S792_pho@Cytosol → 14-3-3*|​unk:​RPTOR|​S722_pho|​S792_pho@Cytosol
12. rc_s7967 → MLST8:​MTOR:​RPTOR|​unk@Nucleus
13. MLST8:​MTOR:​RPTOR|​unk@Nucleus → MLST8:​MTOR:​RPTOR|​unk@PML Body
14. YY1@Nucleus + PPARGC1A@Nucleus + MLST8:​MTOR:​RPTOR|​unk@Nucleus → MLST8:​MTOR:​PPARGC1A:​RPTOR|​pho:​YY1@Nucleus
15. rc_s7967 + FKBP8@Cytosol → FKBP8:​RPTOR|​unk@Cytosol
16. PRAS40*@Cytoplasm + MLST8@Cytoplasm + RPTOR@Cytoplasm + MTOR|​pho@Cytoplasm + RAC1@Cytoplasm → MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
17. PRAS40*@Cytoplasm + MLST8@Cytoplasm + RPTOR@Cytoplasm + MTOR@Cytoplasm + RAC1@Cytoplasm → MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Cytoplasm
18. MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Cytoplasm → MLST8:​MTOR|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
19. MLST8:​MTOR|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
20. MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
21. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome
22. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
23. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
24. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome + PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome
25. DEPTOR@Cytoplasm → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome + DEPTOR:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
26. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → (MLST8:​MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm
27. (MLST8:​MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm + 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​mRNA generic*:​p70_alpha_*@Cytoplasm → 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm
28. 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm → EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm + p70_alpha_*|​T389_pho@Cytoplasm + 4E-BP*|​T37_pho|​T46_pho|​S65_pho|​T70_pho@Cytoplasm
29. EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm + RPS6|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cytoplasm + EIF4B|​pho@Cytoplasm + EIF4G*@Cytoplasm + PABP1*@Cytoplasm + EIF4A*@Cytoplasm → EIF3*:​EIF4A*:​EIF4B|​pho:​EIF4E*:​EIF4G*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PABP1*:​RPS6|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm
30. EIF3*:​EIF4A*:​EIF4B|​pho:​EIF4E*:​EIF4G*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PABP1*:​RPS6|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm → mRNA translation@Cytoplasm

1. gFOXP3@T_cell → rFOXP3@T_cell
2. gMYC@Cytosol → rMYC@Cytosol
3. IFNG@INNATE_IMMUNE_CELL_Cytosol → IFNG@default
4. GZMB@SECRETORY_GRANULE → GZMB@default
5. GZMA@SECRETORY_GRANULE → GZMA@default
6. gIL10@INNATE_IMMUNE_CELL_Cytosol → rIL10@INNATE_IMMUNE_CELL_Cytosol
7. gMMP2@Nucleus → rMMP2@Nucleus
8. 4E-BP1@Cytosol → 4E-BP1|​pho@Cytosol
9. S6K*@Cytosol → S6K*|​pho@Cytosol
10. gMMP9@Nucleus → rMMP9@Nucleus
11. gCytochrome_C*@Nucleus → rCytochrome_C*@Nucleus
12. gPPARGC1A@Nucleus → rPPARGC1A@Nucleus
13. gESRRA@Nucleus → rESRRA@Nucleus
14. gNRF1@Nucleus → rNRF1@Nucleus
15. gPPARGC1B@Nucleus → rPPARGC1B@Nucleus
16. gATP5G1@Nucleus → rATP5G1@Nucleus
17. gCOX5A@Nucleus → rCOX5A@Nucleus
18. gIDH3A@Nucleus → rIDH3A@Nucleus
19. gPHLPP*@Nucleus → rPHLPP*@Nucleus
20. p70_beta_*@Cytoplasm → p70_beta_*|​T388_pho@Cytoplasm
21. ATG13:​FIP200*:​ULK*@Cytoplasm → ATG13|​pho:​FIP200*:​ULK*|​pho@Cytoplasm
22. MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
23. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome
24. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
25. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome + PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome
26. (MLST8:​MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm + 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​mRNA generic*:​p70_alpha_*@Cytoplasm → 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm