Identifiers
HUGO:MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4
HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / TCR_SIGNALING 
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / CORE 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / FATTY_ACID_BIOSYNTHESIS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / RCD_GENES 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / PI3K_AKT_MTOR 

References
PMID:16469695 PMID:26159692 PMID:23087689
PMID:16469695, PMID:26159692
mTOR Complex 1 (mTORC1) is composed of mTOR itself, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8 (MLST8) and the recently identified PRAS40 and DEPTOR
PMID:17680028
PMID:12408816

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / FATTY_ACID_BIOSYNTHESIS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / RCD_GENES 

References
rc_re371( Regulated Cell Death  ):
influenceDelete: re to reactants
engagement of mTOR in mTORC1 does not titrate it out of mTORC2
rc_re1038( Regulated Cell Death  ):
engagement of mTOR in mTORC2 does not titrate it out of mTORC1

References
s_akt1_re113:( Survival  ) PMID:21474067

1. MLST8@Cytoplasm

1. MLST8@Cytosol

1. (MLST8:​MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm
2. MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Cytoplasm
3. MAPKAP1:​MLST8:​MTOR:​PROTOR*:​RAC1:​RICTOR@Cytoplasm
4. 14-3-3*:​MAPKAP1:​MLST8:​MTOR:​PROTOR*:​RICTOR|​T1135_pho@Cytoplasm
5. EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm
6. 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm
7. EIF3*:​EIF4A*:​EIF4B|​pho:​EIF4E*:​EIF4G*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PABP1*:​RPS6|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm

1. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@Cytosol
2. (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@Cytosol

1. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@INNATE_IMMUNE_CELL_Cytosol
2. (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@INNATE_IMMUNE_CELL_Cytosol

1. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft
2. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft
3. DEPTOR:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft
4. 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft

1. MLST8:​MTOR:​RPTOR@Lysosome
2. MLST8:​MTOR|​S2448_pho:​RPTOR@Lysosome
3. GDP:​GTP:​MLST8:​MTOR:​RPTOR:​Rag A/B*:​Rag C/D*@Lysosome

1. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
2. MLST8:​MTOR|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
3. MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
4. MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
5. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
6. DEPTOR:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
7. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome
8. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
9. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome

1. MLST8:​MTOR:​RPTOR|​unk@Nucleus
2. MLST8:​MTOR:​PPARGC1A:​RPTOR|​pho:​YY1@Nucleus

1. MLST8:​MTOR:​RPTOR|​unk@PML Body

1. MAPKAP1:​MLST8:​MTOR:​PRR5:​RICTOR@T_cell
2. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@T_cell
3. (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@T_cell

1. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@T_cell → (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@T_cell
2. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@Cytosol → (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@Cytosol
3. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@INNATE_IMMUNE_CELL_Cytosol → (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@INNATE_IMMUNE_CELL_Cytosol
4. Rag A/B*:​Rag C/D*@Cytosol + mo_s16 → GDP:​GTP:​MLST8:​MTOR:​RPTOR:​Rag A/B*:​Rag C/D*@Lysosome
5. GDP:​GTP:​MLST8:​MTOR:​RPTOR:​Rag A/B*:​Rag C/D*@Lysosome → GDP:​GTP:​Rag A/B*:​Rag C/D*@Lysosome + MLST8:​MTOR:​RPTOR@Lysosome
6. MLST8:​MTOR:​RPTOR@Lysosome → MLST8:​MTOR|​S2448_pho:​RPTOR@Lysosome
7. GDP:​GTP:​MLST8:​MTOR:​RPTOR:​Rag A/B*:​Rag C/D*@Lysosome → Cell cycle / survival / proliferation@Cytosol
8. MAPKAP1@Cytosol + RICTOR@Cytosol + MLST8@Cytosol + MTOR@Cytosol → MAPKAP1:​RICTOR@Cytosol
9. MLST8@Cytosol + MTOR@Cytosol + RPTOR@Cytosol → rc_s5670
10. rc_s7967 → MLST8:​MTOR:​RPTOR|​unk@Nucleus
11. MLST8:​MTOR:​RPTOR|​unk@Nucleus → MLST8:​MTOR:​RPTOR|​unk@PML Body
12. YY1@Nucleus + PPARGC1A@Nucleus + MLST8:​MTOR:​RPTOR|​unk@Nucleus → MLST8:​MTOR:​PPARGC1A:​RPTOR|​pho:​YY1@Nucleus
13. PRAS40*@Cytoplasm + MLST8@Cytoplasm + RPTOR@Cytoplasm + MTOR|​pho@Cytoplasm + RAC1@Cytoplasm → MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
14. PRAS40*@Cytoplasm + MLST8@Cytoplasm + RPTOR@Cytoplasm + MTOR@Cytoplasm + RAC1@Cytoplasm → MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Cytoplasm
15. DEPTOR@Cytoplasm + MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft → DEPTOR:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft
16. 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft → 14-3-3*:​MAPKAP1:​MLST8:​MTOR:​PROTOR*:​RICTOR|​T1135_pho@Cytoplasm
17. MAPKAP1:​MLST8:​MTOR:​PROTOR*:​RAC1:​RICTOR@Cytoplasm → MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft
18. MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Cytoplasm → MLST8:​MTOR|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
19. MLST8:​MTOR|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
20. MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
21. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome
22. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
23. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
24. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome + PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome
25. DEPTOR@Cytoplasm → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome + DEPTOR:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
26. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → (MLST8:​MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm
27. (MLST8:​MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm + 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​mRNA generic*:​p70_alpha_*@Cytoplasm → 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm
28. 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm → EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm + p70_alpha_*|​T389_pho@Cytoplasm + 4E-BP*|​T37_pho|​T46_pho|​S65_pho|​T70_pho@Cytoplasm
29. EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm + RPS6|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cytoplasm + EIF4B|​pho@Cytoplasm + EIF4G*@Cytoplasm + PABP1*@Cytoplasm + EIF4A*@Cytoplasm → EIF3*:​EIF4A*:​EIF4B|​pho:​EIF4E*:​EIF4G*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PABP1*:​RPS6|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm
30. EIF3*:​EIF4A*:​EIF4B|​pho:​EIF4E*:​EIF4G*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PABP1*:​RPS6|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm → mRNA translation@Cytoplasm
31. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft → MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft
32. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft + 14-3-3*@Lipid Raft → 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft

1. gFOXP3@T_cell → rFOXP3@T_cell
2. AKT*@T_cell → AKT*|​Thr450_pho@T_cell
3. AKT*|​Thr308_pho|​Thr450_pho@T_cell → AKT*|​Thr308_pho|​ser473_pho|​Thr450_pho|​active@T_cell
4. gMYC@Cytosol → rMYC@Cytosol
5. IFNG@INNATE_IMMUNE_CELL_Cytosol → IFNG@default
6. GZMB@SECRETORY_GRANULE → GZMB@default
7. GZMA@SECRETORY_GRANULE → GZMA@default
8. gIL10@INNATE_IMMUNE_CELL_Cytosol → rIL10@INNATE_IMMUNE_CELL_Cytosol
9. gMMP2@Nucleus → rMMP2@Nucleus
10. 4E-BP1@Cytosol → 4E-BP1|​pho@Cytosol
11. S6K*@Cytosol → S6K*|​pho@Cytosol
12. gMMP9@Nucleus → rMMP9@Nucleus
13. gCytochrome_C*@Nucleus → rCytochrome_C*@Nucleus
14. gPPARGC1A@Nucleus → rPPARGC1A@Nucleus
15. gESRRA@Nucleus → rESRRA@Nucleus
16. gNRF1@Nucleus → rNRF1@Nucleus
17. gPPARGC1B@Nucleus → rPPARGC1B@Nucleus
18. gATP5G1@Nucleus → rATP5G1@Nucleus
19. gCOX5A@Nucleus → rCOX5A@Nucleus
20. gIDH3A@Nucleus → rIDH3A@Nucleus
21. gPHLPP*@Nucleus → rPHLPP*@Nucleus
22. p70_beta_*@Cytoplasm → p70_beta_*|​T388_pho@Cytoplasm
23. ATG13:​FIP200*:​ULK*@Cytoplasm → ATG13|​pho:​FIP200*:​ULK*|​pho@Cytoplasm
24. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft → AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft
25. AKT1|​T450_emp|​S473_emp|​S129_emp@Cytoplasm → AKT1|​T450_pho|​S473_emp|​active@Cytoplasm
26. MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
27. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome
28. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
29. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome + PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome
30. (MLST8:​MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm + 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​mRNA generic*:​p70_alpha_*@Cytoplasm → 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm
31. SGK1@Cytoplasm → SGK1|​S442_pho@Cytoplasm