Phenotype Membrane spreading map
Membrane spreading@Cytosol

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map
 EMT Senescence  map  / TIGHT_JUNCTIONS  map
 EMT Senescence  map  / GAP_JUNCTIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
 EMT Senescence  map  / DESMOSOMES  map

References
em_emtc_emtc_re983( EMT Senescence  map ):
PMID:9808620
Crk???p130Cas complexes regulate cell spreading after integrin stimulation and serve as amolecular switch for induction of cell migration
DOCK1 is suggested to be the downstream effector of Crk in integrin signaling:
-DOCK1 binds to Crk after integrin stimulation;
-DOCK1 colocalizes with the Crk2???p130Cas complexes at focal adhesions and at the sites of membrane spreading;
-Expression of DOCK1 accelerates the formation of the Crk???p130Cas complexes.
It is likely that the DOCK1 recruited to the Crk???p130Cas complexes on integrin stimulation transduces signals to Rac1 at focal adhesions, which eventually induces cell spreading.
em_emtc_emtc_re984( EMT Senescence  map ):
PMID:17967945
Cell spreading, which is characterized by the formation of filopodia and lamellipodia and represents the outward movement of cell membrane, polymerizing actin, and cytoskeletal complexes at the leading edge. Coordinated spreading and retraction allows cell migration.

Modifications:
In compartment: Cytosol
  1. Membrane spreading@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. DOCK1:​PXN|​pho@Cytosol map → map Membrane spreading@Cytosol map
    2. Membrane spreading@Cytosol map → map Coordination of membrane spreading and retraction@Cytosol map
    3. GTP:​RAC1@Cytosol map → map Membrane spreading@Cytosol map
    4. Lamellipodium formation@Cytosol map → map Membrane spreading@Cytosol map
    5. Filopodium formation@Cytosol map → map Membrane spreading@Cytosol map
    As Catalyser: