Protein FZD*
Identifiers
frizzled family receptor 1
HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38
frizzled family receptor 2
HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332
frizzled family receptor 3
HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1
frizzled family receptor 4
HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1
frizzled family receptor 5
HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467
frizzled family receptor 6
HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353
frizzled family receptor 7
HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084
frizzled family receptor 8
HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461
frizzled family receptor 9
HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144
frizzled family receptor 10
HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2
HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1
HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2
HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3
HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4
HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5
HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6
HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7
HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8
HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence
/ EMT_REGULATORS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ WNT_CANONICAL
Survival
/ WNT_NON_CANONICAL
References
PMID:17884187
Activators: Fz1 Fz4
PMID:19020754
PMID:14704854
PMID:17127310
Modifications:
In compartment: Cytoplasm
- FZD*@Cytoplasm
- FZD*@Cytoplasm
In compartment: Cytosol
- FZD*@Cytosol
Participates in complexes:
In compartment: Cytoplasm
- FZD*:ROR2:WNT3@Cytoplasm
- FZD*:ROR2:WNT1_3*@Cytoplasm
- FZD*:ROR2|pho:WNT3@Cytoplasm
- FZD*:GDP:G_alpha_*:G_beta_*:G_gamma_*@Cytoplasm
- FZD*:GDP:G_alpha_o*:G_beta_*:G_gamma_*@Cytoplasm
- FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:WNT*@Cytoplasm
- FZD*:ROR2|pho:TAB1:TAB2:TAK1*|pho:WNT3@Cytoplasm
- E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:WNT*@Cytoplasm
- E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
- CRIPTO-1*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
- CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:LRP5_6*:WNT*:p120*@Cytoplasm
- CK1_epsilon_*:CTHRC1:FZD*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*@Cytoplasm
- CK1_epsilon_*:CTHRC1:FZD*:PAR6*:PRICKLE1|pho:RACK1*:ROR2|S864_emp|emp|emp:SYN4*:VANGL*|emp|emp|emp|emp:WNT*:_beta_-Arrestin2*@Cytoplasm
- CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:LGR5:LRP5_6*:RSPO1-4*:WNT*:p120*@Cytoplasm
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho:RACK1*:ROR2|S864_emp|emp|emp:SYN4*:VANGL*|emp|emp|emp|emp:WNT*:_beta_-Arrestin2*@Cytoplasm
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SMURF1:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho|ubi:PRR*:RACK1*:ROR2:SMURF1:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
- CK1_epsilon_*:CTHRC1:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*@Cytoplasm
- APC2*:CK1_epsilon_*:CTHRC1:DAAM1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*|pho|pho|pho|pho:WGEF*:WNT*:_beta_-Arrestin2*@Cytoplasm
- APC2*:CK1_epsilon_*:CTHRC1:DAAM1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:RHOA:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*|pho|pho|pho|pho:WGEF*:WNT*:_beta_-Arrestin2*@Cytoplasm
In compartment: Cytosol
- FZD*:LRP5_6*:WNT*@Cytosol
- DVL1:FZD*:LRP5_6*:WNT*@Cytosol
In compartment: Endosome
- AMER1*:CK1_gamma_*:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
- AMER1*:CK1_gamma_*:DVL*|pho|pho|pho|pho:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RAC1:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
- APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_gamma_*:DVL*|pho|pho|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
- APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*|pho|pho|pho|pho:WNT*:_beta_-Arrestin2*@Endosome
- APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:PRR*:RACK1*:ROR2|S864_pho:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*|S268_pho|S269_pho@Endosome
- AMER1*:APC:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
In compartment: Vaceolae
- CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:p120*@Vaceolae
- AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae
- AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae
Participates in reactions:
As Reactant or Product:- FZD*@Cytosol
+ WNT*@Extracellular space
+ LRP5_6*@Cytosol
→
FZD*:LRP5_6*:WNT*@Cytosol
- DVL1@Cytosol
+ FZD*:LRP5_6*:WNT*@Cytosol
→
DVL1:FZD*:LRP5_6*:WNT*@Cytosol
- WNT*@default
+ CK1_epsilon_*:E-Cadherin*:LRP5_6*:p120*@Vaceolae
+ FZD*:GDP:G_alpha_o*:G_beta_*:G_gamma_*@Cytoplasm
+ GTP@Vaceolae
+ PRR*@Cytoplasm
→
CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:p120*@Vaceolae
+ GDP@Vaceolae
- DVL*|pho|emp|emp:G_beta_*:G_gamma_*:_beta_-Arrestin2*@Cytoplasm
+ CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:p120*@Vaceolae
+ AMER1*:CK1_gamma_*:PtdIns(4,5)-P2@Cytoplasm
→
AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae
+ GTP:G_alpha_o*@Cytoplasm
+ G_beta_*:G_gamma_*@Cytoplasm
- AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae
→
AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae
- AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae
+ AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*@Cytoplasm
→
AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
→
AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
+ AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*@Cytoplasm
→
AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
→
AMER1*:APC:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
- AMER1*:APC:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
→
AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
→
AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*|S268_pho|S269_pho@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*|S268_pho|S269_pho@Endosome
→
CK1_epsilon_*:p120*|S268_pho|S269_pho@Endosome
+ E-Cadherin*|pho@Endosome
+ AMER1*:AXIN*:CK1_alpha_*:CK1_gamma_*:DVL*|pho|pho|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_gamma_*:DVL*|pho|pho|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
→
AMER1*:CK1_gamma_*:DVL*|pho|pho|pho|pho:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
+ AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*@Endosome
- AMER1*:CK1_gamma_*:DVL*|pho|pho|pho|pho:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
→
Recycling @Cytoplasm
- AMER1*:CK1_gamma_*:DVL*|pho|pho|pho|pho:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
→
Degradation@Cytoplasm
- AMER1*:CK1_gamma_*:DVL*|pho|pho|pho|pho:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
→
DVL*|pho|pho|pho|pho@Endosome
+ AMER1*:CK1_gamma_*:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
- E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
→
LRP5_6*@Cytoplasm
+ E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:WNT*@Cytoplasm
- LRP5_6*@Cytoplasm
→
E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
- E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
→
WNT canonical pathway@Cytoplasm
- CRIPTO-1*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
→
WNT canonical pathway@Cytoplasm
- E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:WNT*@Cytoplasm
+ CRIPTO-1*:LRP5_6*@Cytoplasm
→
CRIPTO-1*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
- WNT1_3*@Extracellular space
+ FZD*@Cytoplasm
+ ROR2@Cytoplasm
→
FZD*:ROR2:WNT1_3*@Cytoplasm
- FZD*:ROR2:WNT1_3*@Cytoplasm
→
TAB1:TAK1*@Cytoplasm
- RAC1@Cytoplasm
+ CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
→
CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RAC1:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
- APC2*:GSK3*@Cytoplasm
+ CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
→
APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:PRR*:RACK1*:ROR2|S864_pho:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho|ubi:PRR*:RACK1*:ROR2:SMURF1:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
+ RSPO3@Cytoplasm
→
CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
+ SMURF1@Cytoplasm
+ PRICKLE1|pho|ubi@Cytoplasm
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
→
CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
→
CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RAC1:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
→
RAC1@Cytoplasm
+ CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
- APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*|pho|pho|pho|pho:WNT*:_beta_-Arrestin2*@Endosome
+ WGEF*@Cytoplasm
+ DAAM1@Cytoplasm
+ RHOA@Cytoplasm
→
APC2*:CK1_epsilon_*:CTHRC1:DAAM1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:RHOA:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*|pho|pho|pho|pho:WGEF*:WNT*:_beta_-Arrestin2*@Cytoplasm
- APC2*:CK1_epsilon_*:CTHRC1:DAAM1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*|pho|pho|pho|pho:WGEF*:WNT*:_beta_-Arrestin2*@Cytoplasm
→
Angiogenesis@Nucleus
- APC2*:CK1_epsilon_*:CTHRC1:DAAM1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:RHOA:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*|pho|pho|pho|pho:WGEF*:WNT*:_beta_-Arrestin2*@Cytoplasm
→
APC2*:CK1_epsilon_*:CTHRC1:DAAM1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*|pho|pho|pho|pho:WGEF*:WNT*:_beta_-Arrestin2*@Cytoplasm
+ RHOA@Cytoplasm
- LGR5:RSPO1-4*@Cytoplasm
+ CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:LRP5_6*:WNT*:p120*@Cytoplasm
→
CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:LGR5:LRP5_6*:RSPO1-4*:WNT*:p120*@Cytoplasm
- CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:LGR5:LRP5_6*:RSPO1-4*:WNT*:p120*@Cytoplasm
→
WNT canonical pathway@Cytoplasm
- WNT*@default
+ FZD*:GDP:G_alpha_*:G_beta_*:G_gamma_*@Cytoplasm
+ GTP@Cytoplasm
→
FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:WNT*@Cytoplasm
+ GDP@Cytoplasm
- FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:WNT*@Cytoplasm
→
G_beta_*:G_gamma_*@Cytoplasm
+ GTP:G_alpha_*@Cytoplasm
- ROR2@Cytoplasm
+ FZD*:GDP:G_alpha_*:G_beta_*:G_gamma_*@Cytoplasm
+ WNT*@default
+ GTP@Cytoplasm
+ CK1_epsilon_*@Cytoplasm
+ CTHRC1@Cytoplasm
+ SYN4*@Cytoplasm
+ PAR6*:PRICKLE1|pho:RACK1*:VANGL*@Cytoplasm
+ PRR*@Cytoplasm
→
CK1_epsilon_*:CTHRC1:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*@Cytoplasm
+ GDP@Cytoplasm
- CK1_epsilon_*:CTHRC1:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*@Cytoplasm
→
GTP:G_alpha_*@Cytoplasm
+ CK1_epsilon_*:CTHRC1:FZD*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*@Cytoplasm
+ G_beta_*:G_gamma_*@Cytoplasm
- CK1_epsilon_*:CTHRC1:FZD*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*@Cytoplasm
+ DVL*|pho|S142_emp|S139_emp:_beta_-Arrestin2*@Cytoplasm
→
CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
- APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:PRR*:RACK1*:ROR2|S864_pho:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
→
WNT canonical pathway@Cytoplasm
- APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:PRR*:RACK1*:ROR2|S864_pho:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
→
APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
- APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
→
APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*|pho|pho|pho|pho:WNT*:_beta_-Arrestin2*@Endosome
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho:RACK1*:ROR2|S864_emp|emp|emp:SYN4*:VANGL*|emp|emp|emp|emp:WNT*:_beta_-Arrestin2*@Cytoplasm
→
CK1_epsilon_*:CTHRC1:FZD*:PAR6*:PRICKLE1|pho:RACK1*:ROR2|S864_emp|emp|emp:SYN4*:VANGL*|emp|emp|emp|emp:WNT*:_beta_-Arrestin2*@Cytoplasm
+ DVL*|pho|S142_emp|S139_emp|ubi@Cytoplasm
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
→
CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho:RACK1*:ROR2|S864_emp|emp|emp:SYN4*:VANGL*|emp|emp|emp|emp:WNT*:_beta_-Arrestin2*@Cytoplasm
- SMURF1@Cytoplasm
+ CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
→
CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SMURF1:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
- CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SMURF1:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
→
CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho|ubi:PRR*:RACK1*:ROR2:SMURF1:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
- FZD*:ROR2:WNT3@Cytoplasm
→
FZD*:ROR2|pho:WNT3@Cytoplasm
- TAB1:TAB2:TAK1*|pho@Cytoplasm
+ FZD*:ROR2|pho:WNT3@Cytoplasm
→
FZD*:ROR2|pho:TAB1:TAB2:TAK1*|pho:WNT3@Cytoplasm
- FZD*:ROR2|pho:TAB1:TAB2:TAK1*|pho:WNT3@Cytoplasm
→
WNT canonical pathway@Cytoplasm
- WNT3@default
+ ROR2@Cytoplasm
+ FZD*@Cytoplasm
→
FZD*:ROR2:WNT3@Cytoplasm
As Catalyser:- AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae
→
AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae
- AMER1*:APC:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
→
AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
→
AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*|S268_pho|S269_pho@Endosome
- DVL*@Cytoplasm
+ CUL3:KLHL*:RBX1@Cytoplasm
→
CUL3:DVL*:KLHL*:RBX1@Cytoplasm
- JBN*:_beta_-Catenin*@Cytoplasm
→
JBN*:_beta_-Catenin*@Cilium
- JBN*:_beta_-Catenin*@Cilium
→
su_wca1_s_wca1_s764
- ATP6V0C_D*@Vaceolae
→
ATP6V0C_D*@Vaceolae
- ATP6V0C_D*@Cytoplasm
→
ATP6V0C_D*@Endosome
- ATP6V0C_D*@Cytoplasm
→
ATP6V0C_D*@Endosome
- APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:PRR*:RACK1*:ROR2|S864_pho:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
→
APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome