Reaction dissociation su_wnc1_s_wnc1_re111
CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho|ubi:PRR*:RACK1*:ROR2:SMURF1:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
+ RSPO3@Cytoplasm
→ CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
+ SMURF1@Cytoplasm
+ PRICKLE1|pho|ubi@Cytoplasm
No reaction regulators
References
Rspo is required for clathrin-mediated endocytosis
PMID:21397842
It has been shown that Dvl polymers are not associated with vesicles, therefore endocytosis of the complex is likely to be after Dvl polymerisation.
PMID:16263762