Protein DVL1 map

Identifiers
dishevelled, dsh homolog 1 (Drosophila)
HUGO:DVL1, HGNC:3084, ENTREZ:1855, UNIPROT:O14640??, GENECARDS:GC01M001262
"dishevelled 1 (homologous to Drosophila dsh)"
HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
PMID:19751508
PMID:22270359
PMID:16940750
in the absence of Wnt ligands, b-catenin is phosphorylated by CK1 and GSK-3 in the context of a destruction complex with APC and Axin.
Phosphorylated b-catenin is consequently targeted for ubiquitination and degraded.
Upon ligand binding, DVL1 (dishevelled) recruits the Axin-GSK-3 complex, resulting in the sequential phosphorylation of LRP6 by CK1 and GSK-3.
Phoshorylated LRP6 serves as a docking site for additional Axin-GSK-3 complex, resulting in the disassembly of the destruction complex.
Non phosphorylated and thus stabilized b-catenin translocates to the nucleus where it activates transcription of target genes together with LEF/TCFs

DVL1@Cytosol

References
em_emtc_emtc_re466( EMT Senescence  map ):
PMID:10428961
PMID:8666229
Wnt transduces their signals through DVL1 to inhibit GSK3B, leading to the accumulation of cytosolic CTNNB1 and activation of TCF/LEF1 transcription factors.
DVL1 interacts with AXIN1 and with Frat1.
Binding of AXIN1 to DVL1 reduces formation of the destruction complex APC/AXIN1.

DVL1@Nucleus

References
s_wca4_re33:( Survival  map ) PMID:20439735

Modifications:
In compartment: Cytosol
  1. DVL1@Cytosol map
In compartment: Nucleus
  1. DVL1@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. AXIN1:​DVL1:​FRAT1@Cytosol map
  2. DVL1:​FZD*:​LRP5_6*:​WNT*@Cytosol map
In compartment: Nucleus
  1. DVL1:​SIRT1_2*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. DVL1@Cytosol map + FZD*:​LRP5_6*:​WNT*@Cytosol map → map DVL1:​FZD*:​LRP5_6*:​WNT*@Cytosol map
  2. AXIN1@Cytosol map + DVL1@Cytosol map + FRAT1@Cytosol map → map AXIN1:​DVL1:​FRAT1@Cytosol map
  3. rDVL1@Nucleus map → map DVL1@Nucleus map
  4. DVL1@Nucleus map + SIRT1_2*@Nucleus map → map DVL1:​SIRT1_2*@Nucleus map
  5. DVL1:​SIRT1_2*@Nucleus map → map Transcription of WNT-target genes@Nucleus map
As Catalyser: