Identifiers
NAME:LRP5_6*:WNT*
References
s_wnc2_re1( Survival ):
Wnt5 can binds to LRP5/6 and in this way, physiologically inhibits non-canonical pathway. In Xenopus and mice.
PMID:19056682
s_wnc2_re3( Survival ):
Binding of Wnt5 and LRP5/6 leads to phosphorylation of Dvl. Most likely the same residues as picture shows same speed of migration on gel compared to Wnt3 stimulation. No phosphorylation of LRP5/6 by Wnt5. This complex formation sequesters away Wnt5 from the non-canonical pathway receptors
su_wnc1_s_wnc2_re3( Survival ):