WRN

Protein WRN

Identifiers
Werner syndrome RecQ like helicase
HUGO:WRN
Werner syndrome, RecQ helicase-like
HUGO:WRN, HGNC:12791, ENTREZ:7486, UNIPROT:Q14191

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / BER
Cell Cycle DNA Repair / A_NHEJ
Cell Cycle DNA Repair / HR

References
PMID:11283614
Myc: an ubiquitous mediator of cell growth and proliferation
Myc can both activate and repress transcription, depending on the nature of associated factors
TGFB downregulates Myc to cause cell cycle arrest.
TGFB activates p15INK4B and/or p21CIP1 (inhibitor of CDKs) ==> CDK inhibition by TGFB
TGFB downregulates cdc25A (a phosphatase, activator of CDKs) ==> CDK inhibition by TGFB
PMID:2191300
Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter.
PMID??:28536364
c-myc is transcriptionally upregulated by NF-??B
PMID:20027199
MYC induces DNA damage throuh an increase in ROS production, innapropriate DNA synthesis and abrogation of DNA repair
PMID:20713526
MYC supress the activity of anti-apoptotic BCL2 and BCLXL (BCL2L1) genes
PMID??:20713526
MYC in complex with CDK2 alone inhibit senescence through the inhibition of p16 and p21 expression as well as TERT and BMI1 expression increase. MYC in complex with CDK2 and p27KIP1 induces senescence through the expression increase of p16 and p21 as well as TERT and BMI1 expression decrease. WRN inhibit MYC induced senescence.
PMID??: PMID:17055429
MYC stimulate P53 and ARF
PMID:24709898
PMID:20691907
For A_NHEJ pathway
(alt_NHEJ or B_NHEJ or MMEJ)
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
, PMID:21376743, PMID:24050180, PMID:22743550
For HR pathway
PMID:19490890, PMID:22657828
For BER pathway
PMID:17116323, PMID:18398454, PMID:16449207, PMID:15385537, PMID:18558713, PMID:23161013
WRN in telomere maintenance
PMID:23253856
Resolving stalled replication fork
Inhibiting WNT kills alt_NHEJ pathway
PMID:24036544
PARP1 inhibits WRN
PMID:23082994
WRN inhibits C_NHEJ by sequestering DNA-PKs
PMID:12202749
Activation of WRN in cancers
http://www.intechopen.com/download/get/type/pdfs/id/22156
http://www.intechopen.com/download/get/type/pdfs/id/19301
PMID:18524993

WRN@Nucleus

References
em_emtc_emtc_re275( EMT Senescence ):
PMID:9618481
-Smad4 transactivated the proximal p21 promoter 1.3-fold
-Smad2 transactivated the proximal p21 promoter 3-fold
-Smad2/4 transactivated the proximal p21 promoter 12-fold
-Smad3 transactivated the proximal p21 promoter 25-fold
-Smad3/Smad2 transactivated the proximal p21 promoter 40-fold
-Smad3/Smad4 transactivated the proximal p21 promoter 110-fold
-Smad2/Smad3/Smad4 transactivated the proximal p21 promoter 140-fold
Smad proteins act as Transcriptional Activators via functional interactions with the Transcription factor Sp1
PMID:12545156
Myc represses differentiation-induced p21 expression via Miz-1-dependent interaction with the p21 core promoter
Myc binds the p21 core promoter in vitro through interaction with Miz-1
Myc and Miz-1 interact with the p21 promoter in vivo
PMID:15155580
Snail regulates cell-cycle progression and survival:
Snail regulates components of the early to late G1 transition and the G1/S checkpoint.
Snail represses Cyclin D2 transcription and increases p21/Cip1 transcription.
PMID:17550342
SNAI2 induces p21CIP1 (CDKN1A) expression
PMID:23869868
PMID:23140366
p53 transactivate p21
PMID:11283614
Myc: an ubiquitous mediator of cell growth and proliferation
Myc can both activate and repress transcription, depending on the nature of associated factors
TGFB downregulates Myc to cause cell cycle arrest.
TGFB activates p15INK4B and/or p21CIP1 (inhibitor of CDKs) ==> CDK inhibition by TGFB
TGFB downregulates cdc25A (a phosphatase, activator of CDKs) ==> CDK inhibition by TGFB
PMID:2191300
Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter.
PMID??:28536364
c-myc is transcriptionally upregulated by NF-??B
PMID:20027199
MYC induces DNA damage throuh an increase in ROS production, innapropriate DNA synthesis and abrogation of DNA repair
PMID:20713526
MYC supress the activity of anti-apoptotic BCL2 and BCLXL (BCL2L1) genes
PMID??:20713526
MYC in complex with CDK2 alone inhibit senescence through the inhibition of p16 and p21 expression as well as TERT and BMI1 expression increase. MYC in complex with CDK2 and p27KIP1 induces senescence through the expression increase of p16 and p21 as well as TERT and BMI1 expression decrease. WRN inhibit MYC induced senescence.
PMID??: PMID:17055429
MYC stimulate P53 and ARF
em_emtc_emtc_re1197( EMT Senescence ):
PMID:21919891
PMID:21733352
Direct activation of Bmi1 expression by Twist1 using transient transfection.
PMID:20818389
Twist1 directly activates BMI1 transcription by binding to the E-box in intron 1 of the BMI1 gene.
SNAI2 induces BMI1 expression

WRN|unk@Nucleus

References
ce_re564:( Cell Cycle DNA Repair ) PMID:23082994

WRN|ace@Nucleus

References
ce_re22( Cell Cycle DNA Repair ):
PMID:18398454
PMID:16449207
RECQL5 activates BER via XRCC1 and PARP1
PMID:22973052

Modifications:
In compartment: Nucleus

WRN@Nucleus
WRN|ace@Nucleus
WRN|unk@Nucleus

Participates in complexes:
In compartment: Nucleus

Participates in reactions:
As Reactant or Product:

As Catalyser: