Protein CHEK2 map

Identifiers
CHK2 checkpoint homolog (S. pombe)
HUGO:CHEK2, HGNC:16627, ENTREZ:11200, Q9UGF0

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / G1_S_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / S_PHASE_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map

References
PMID:15459660, PMID:15810020, PMID:18566216, PMID:17464182

CHEK2|​pho|​active@Nucleus

References
ce_re34:( Cell Cycle DNA Repair  map ) PMID:19788416
ce_re65( Cell Cycle DNA Repair  map ):
Phosphorylation of CDC25A, B or C by CHEK1 and CHEK2 inactivates CDC25, prevents activating de-phosphorylation of CDKs by CDC25 A, B, C
and stops cell cycle propagation
kegg cell cycle
PMID:20126263, PMID:17568790
ce_re70:( Cell Cycle DNA Repair  map ) PMID:18971944
ce_re71( Cell Cycle DNA Repair  map ):
For inactivation of EXO1 by 53BP1-mediated phosphorylation:
PMID:18756267, PMID:15867354
ATM and ATR phosphorylate EXO1 and lead to EXO1 ubiquitination and degradation:
PMID:18048416, PMID:11438669, PMID:20019063
ce_re188( Cell Cycle DNA Repair  map ):
PMID:18931676, PMID:19686080, PMID:17296736
Link between cell cycle and activation of Fanconi pathway

Modifications:
In compartment: Nucleus
  1. CHEK2@Nucleus map
  2. CHEK2|​pho|​active@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. CHEK2@Nucleus map → map CHEK2|​pho|​active@Nucleus map
    As Catalyser:
    1. FANCE@Nucleus map → map FANCE|​S376_pho|​T346_pho@Nucleus map
    2. CDC25C@Nucleus map → map CDC25C|​S216_pho@Nucleus map
    3. p53*@Nucleus map → map p53*|​pho|​ace|​active@Nucleus map
    4. BRCA1@Nucleus map → map BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@Nucleus map
    5. CDC25A@Nucleus map → map CDC25A|​S76_pho|​S178_pho|​S124_pho|​S279_pho|​S293_pho@Nucleus map
    6. CDC25B@Nucleus map → map CDC25B|​S230_pho|​S151_pho|​S323_pho@Nucleus map
    7. XRCC1@Nucleus map → map XRCC1|​pho@Nucleus map
    8. EXO1@Nucleus map → map EXO1|​S692_pho|​S372_pho|​S567_pho|​S587_pho@Nucleus map