ATM

Protein ATM

Identifiers
Ataxia telangiectasia mutated
HUGO:ATM, HGNC:795, ENTREZ:472, UNIPROT:Q13315
Ataxia-telangectasia mutated
HUGO:ATM, HGNC:795, ENTREZ:472, UNIPROT:Q13315, GENECARDS:ATM
ATA "ataxia telangiectasia mutated (includes complementation groups A C and D)" ATC ATD ATDC

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G1_S_CHECKPOINT
Cell Cycle DNA Repair / S_PHASE_CHECKPOINT
Cell Cycle DNA Repair / G2_M_CHECKPOINT
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / RCD_GENES
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK

References
MDM2 phosphorylation by ATM inhibits its interaction with p53
PMID:15140942
Phosphorylation at Ser395
PMID:11331603
DDR by ATM
PMID:23847781
PMID:17303408, PMID:16163361, PMID:15964794
For S-phase checkpoint
PMID:15459660, PMID:12607003, PMID:11877377

ATM@Nucleus

References
em_emtc_emtc_re1210( EMT Senescence ):
MDM2 phosphorylation by ATM inhibits its interaction with p53
PMID:15140942
Phosphorylation at Ser395
PMID:11331603

ATM|S1981_pho|S367_pho|S1893_pho|active@Nucleus

References
ce_re36( Cell Cycle DNA Repair ):
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707
ce_re32:( Cell Cycle DNA Repair ) PMID:19788416, PMID:9168117, PMID:11804596
ce_re33:( Cell Cycle DNA Repair ) PMID:15485915
ce_re43:( Cell Cycle DNA Repair ) PMID:16731533
ce_re71( Cell Cycle DNA Repair ):
For inactivation of EXO1 by 53BP1-mediated phosphorylation:
PMID:18756267, PMID:15867354
ATM and ATR phosphorylate EXO1 and lead to EXO1 ubiquitination and degradation:
PMID:18048416, PMID:11438669, PMID:20019063
ce_re82:( Cell Cycle DNA Repair ) PMID:21376743
ce_re97:( Cell Cycle DNA Repair ) PMID:17303408, PMID:16163361, PMID:15964794
ce_re110( Cell Cycle DNA Repair ):
Phosphorylation by ATM and ATR at T847, S327
Phosphorylation at S327 by ATM and ATR are essential for shift from A_NHEJ to HR
Phosphorylation by CDC2(CDK1) in cell cycle dep manner to shift from C_NHEJ ot HR at: Ser 267
This phosphorylation allows resection that initiates HR and blocks binding of Ku70/Ku80 complex that initiates C_NHEJ.
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
BRCA1 and CtIP interactions make shift from A_NHEJ and C_NHEJ toward HR
Resected DNA in HR is a positive trigger for amplification of the HR pathway (positive loop):
PMID:20051983
Only when CDKs are fully active, this fully activates HR during S and G2 phases:
PMID:18511906, PMID:18716619
ce_re115( Cell Cycle DNA Repair ):
PMID:16581787,
For inhibition of S-checkpoint by ATM:
PMID:15175241
Inhibition of Sphase by MRE complex:
PMID:17713585
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
ce_re119( Cell Cycle DNA Repair ):
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
PMID:18469862
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
PMID:19342888
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
PMID:16713580
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767
ce_re132:( Cell Cycle DNA Repair ) PMID:19841479, PMID:19793861
ce_re148( Cell Cycle DNA Repair ):
PMID:18006705
PMID:18583988
ce_re198( Cell Cycle DNA Repair ):
ATM phosphotylates FANCD2 for S-phase checkpoint arrest in responce to IR.
PMID:12086603
ce_re408:( Cell Cycle DNA Repair ) PMID:9858600

ATM|unk|K3016_unk@Nucleus

Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / RCD_GENES

References
rc_re1239:( Regulated Cell Death ) reactionType:is.a
rc_re1241( Regulated Cell Death ):
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:10454555
in HL60
in vitro

ATM|hm2@Site of DNA damage

References
rc_re1485( Regulated Cell Death ):
influenceDelete: re to reactants
PMID:17486112
by NBN
rc_re1510:( Regulated Cell Death ) reactionType:is.a

ATM|pho|K3016_ace@Site of DNA damage

References
rc_re1046( Regulated Cell Death ):
PMID:12234250
in G361 human melanoma cells, upon ionizing radiations
in vitro by ATM and DNAPK
in Hela, ectopically expressed LKB1 T366-phosphorylated is located in the nucleus
PMID:20160076
in HeLa S3 cells that lack functional LKB1, reexpression of wild-type but not T366A LKB1 restored the ability to repress mTORC1 in response to H2O2
in MCF7, LKB1 is located in the cytoplasm, together with a proportion of ATM. H2O2 induces phosphorylation of cytoplasmic LKB1, but not other DNA damaging agents (etoposide). This supports a possible H2O2-induced and DNA damage-independent activation of the cytoplasmic of ATM responsible for LKB1 phosphorylation.
rc_re1128:( Regulated Cell Death ) PMID:23030059
rc_re1240:( Regulated Cell Death ) reactionType:is.a
rc_re1480( Regulated Cell Death ):
PMID:18001824
PMID:18006705
rc_re1488( Regulated Cell Death ):
influenceDelete: re to reactants
PMID:9488723
PMID:11571274

ATM|hm2@Nucleus

References
rc_re1239:( Regulated Cell Death ) reactionType:is.a
rc_re1485( Regulated Cell Death ):
influenceDelete: re to reactants
PMID:17486112
by NBN

ATM@Cytoplasm

References
su_mpk1_mpk1_re179( Survival ):
P53 is a nuclear P38 target.
Activated P38 phosphorylates P53 at several residues including Ser33 and thereby increases the transcriptional activity of P53.
ATM phosphorylates P53 at ser15 and stabilize it.
PMID:20506250 PMID:21614932 PMID:15140942
su_mpk1_mpk1_re255( Survival ):
Ataxia telangiectasia mutated (ATM) is activated in response to DNA damage and directly phosphorylates TAOK.
PMID:18855897

Modifications:
In compartment: Cytoplasm

ATM@Cytoplasm

In compartment: Nucleus

ATM@Nucleus
ATM|hm2@Nucleus
ATM|unk|K3016_unk@Nucleus
ATM|S1981_pho|S367_pho|S1893_pho|active@Nucleus

In compartment: Site of DNA damage

ATM|hm2@Site of DNA damage
ATM|pho|K3016_ace@Site of DNA damage

Participates in complexes:
In compartment: Nucleus

Participates in reactions:
As Reactant or Product:

As Catalyser: