Protein Ku70* map

Identifiers
X-ray repair complementing defective repair in Chinese hamster cells 6
HUGO:XRCC6, HGNC:4055, ENTREZ:2547, UNIPROT:P12956

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / C_NHEJ  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258,
PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180
Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ
PMID:17088286
synonym:Ku70

Ku70*@Nucleus

References
ce_re85:( Cell Cycle DNA Repair  map ) PMID:9242410

Ku70*|​K539_ace|​K542_ace@Nucleus

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re472( Regulated Cell Death  map ):
PMID:15205477
in 293T cells Sirt1 attenuates BAX mediated apoptosis by deacetylating Ku70
identification of acetylation sites on Ku70 by use of synthetic acetylated peptides

Ku70*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re473:( Regulated Cell Death  map ) PMID:17116881
rc_re19( Regulated Cell Death  map ):
PMID:12652308
in HEK293
Ku70 KO in MEFs results in hypersensitivity to apoptosis

Modifications:
In compartment: Cytosol
  1. Ku70*@Cytosol map
In compartment: Nucleus
  1. Ku70*@Nucleus map
  2. Ku70*|​K539_ace|​K542_ace@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. Ku70*:​Ku80*@Nucleus map
  2. Ku70*:​Ku80*:​Securin*@Nucleus map
  3. DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map
  4. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map
  5. APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. Ku70*:​Ku80*@Nucleus map + Securin*@Nucleus map → map Ku70*:​Ku80*:​Securin*@Nucleus map
  2. Ku80*@Nucleus map + Ku70*@Nucleus map + WRN@Nucleus map + DNA-PK*@Nucleus map → map DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map
  3. Ku70*@Nucleus map + Ku80*@Nucleus map → map Ku70*:​Ku80*@Nucleus map
  4. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@Nucleus map + LIG4:​XLF*:​XRCC4|​hm2@Nucleus map + PARP3@Nucleus map + DNA-PK*|​hm2|​active@Nucleus map + Ku80*@Nucleus map + Ku70*@Nucleus map + APLF@Nucleus map → map APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map
  5. DNA-PK*|​hm2|​active@Nucleus map + Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@Nucleus map + Ku70*:​Ku80*@Nucleus map + PARP3@Nucleus map → map Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map
  6. BAX@Cytosol map + Ku70*@Cytosol map → map rc_s99
  7. Ku70*|​K539_ace|​K542_ace@Nucleus map → map Ku70*@Nucleus map
  8. Ku70*@Nucleus map → map Ku70*@Cytosol map
As Catalyser:
  1. gA_NHEJ_DNA_st1*@Nucleus map → map gA_NHEJ_DNA_st2*@Nucleus map
  2. gC_NHEJ_DNA_st1*@Nucleus map → map gC_NHEJ_DNA_st2*@Nucleus map
  3. gC_NHEJ_DNA_st3*@Nucleus map → map gC_NHEJ_DNA_st4*@Nucleus map
  4. gC_NHEJ_DNA_st4*@Nucleus map → map gC_NHEJ_DNA_st5*@Nucleus map