ATM:MRE11*:NBS1*:RAD50

Complex ATM:MRE11*:NBS1*:RAD50

Complex composition:

ATM|S1981_pho|S367_pho|S1893_pho:MRE11*:NBS1*|S343_pho:RAD50@Nucleus

Identifiers
NAME:ATM:MRE11*:NBS1*:RAD50

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / G2_M_CHECKPOINT
Cell Cycle DNA Repair / HR
Cell Cycle DNA Repair / A_NHEJ

References
PMID:17303408, PMID:16163361, PMID:15964794
ce_re90( Cell Cycle DNA Repair ):
PMID:9488723, PMID:19772495
PMID:17303408
ce_re114( Cell Cycle DNA Repair ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833
ce_re122( Cell Cycle DNA Repair ):
PMID:20064462,
MRN complex in A_NHEJ: PMID:19362533, PMID:19654615, PMID:19892829

Modifications:
Participates in complexes:
In compartment: Nucleus

Participates in reactions:
As Reactant or Product:

As Catalyser: