Gene A_NHEJ_DNA_st1* map

Identifiers
DNA with double strand break
Node_Type:Generic

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / A_NHEJ  map

References
PMID:23892398
For A_NHEJ:
PMID:22258607, PMID:22918414, PMID:21376743, PMID:24050180, PMID:22743550, PMID:23897299
Double strand break trigers MRN complex association, the first step in DNA damage recognition and initiation of G2/M checkpoint
PMID:17303408

gA_NHEJ_DNA_st1*@Nucleus

References
ce_re514( Cell Cycle DNA Repair  map ):
http://dnatraffic.ibb.waw.pl/classification/dna_damages
PMID:22258607, PMID:19267553, PMID:18256616
For activation by Dbait
PMID:22068457, PMID:22815765, PMID:22042585, PMID:19621083
ce_re599:( Cell Cycle DNA Repair  map ) reactionType:is.a
ce_re36( Cell Cycle DNA Repair  map ):
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707
ce_re91( Cell Cycle DNA Repair  map ):
MRN complex:
PMID:16531125, PMID:17303408
Double strand breaks sensor.
MRN complex association is a first event after the DNA damage.
ce_re105( Cell Cycle DNA Repair  map ):
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737
ce_re199( Cell Cycle DNA Repair  map ):
HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase:
PMID:19282663, PMID:19622404, PMID:18995830
ce_re260( Cell Cycle DNA Repair  map ):
DNA with O6-methylguanine adducts, MutSalpha and MutLalpha activate ATR/ATRIP and BER pathways performs the repair:
PMID:16713580, PMID:18543256
Damaged DNA triggers ATR/ATRIP complex activation

Modifications:
In compartment: Nucleus
  1. gA_NHEJ_DNA_st1*@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gA_NHEJ_DNA_st1*@Nucleus map → map gA_NHEJ_DNA_st2*@Nucleus map
    2. gDeaminated_alkylated_mismatched_base*@Nucleus map → map gA_NHEJ_DNA_st1*@Nucleus map
    3. gA_NHEJ_DNA_st1*@Nucleus map → map gDamaged_DNA*@Nucleus map
    4. gOxidized_ring-saturated_hydrolysed_base*@Nucleus map → map gA_NHEJ_DNA_st1*@Nucleus map
    5. gIntact_DNA*@Nucleus map → map gA_NHEJ_DNA_st1*@Nucleus map
    6. gDouble_strand_breaks_DSB*@Nucleus map → map gA_NHEJ_DNA_st1*@Nucleus map
    As Catalyser:
    1. HCLK2*@Nucleus map + FAAP24*@Nucleus map + FANCM@Nucleus map + ATR|​pho|​active@Nucleus map → map ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@Nucleus map
    2. ATR|​pho|​active@Nucleus map + ATRIP@Nucleus map → map ATRIP:​ATR|​pho@Nucleus map
    3. ATM@Nucleus map → map ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@Nucleus map
    4. PPP5C:​RAD17@Nucleus map → map PPP5C@Nucleus map + RAD17@Nucleus map
    5. MRE11*@Nucleus map + RAD50@Nucleus map + NBS1*|​S343_pho@Nucleus map → map MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map