Protein RAD50 map

Identifiers
RAD50 homolog (S. cerevisiae)
HUGO:RAD50, HGNC:9816, ENTREZ:10111, UNIPROT:Q92878

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / S_PHASE_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / HR  map
 Cell Cycle DNA Repair  map  / A_NHEJ  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map

References
PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763
For S-phase checkpoint
PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003
For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ):
PMID:21376743, PMID:24050180, PMID:22743550

RAD50@Nucleus

References
ce_re91( Cell Cycle DNA Repair  map ):
MRN complex:
PMID:16531125, PMID:17303408
Double strand breaks sensor.
MRN complex association is a first event after the DNA damage.

RAD50@Site of DNA damage

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map

References
rc_re1477( Regulated Cell Death  map ):
influenceDelete: re to reactants
PMID:18813293
review
through RAD50

Modifications:
In compartment: Nucleus
  1. RAD50@Nucleus map
In compartment: Site of DNA damage
  1. RAD50@Site of DNA damage map
Participates in complexes:
In compartment: Nucleus
  1. MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
  2. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
  3. ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
  4. ATM|​S1981_pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​MRE11*:​NBS1*|​S343_pho:​RAD50:​WRN@Nucleus map
  5. ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
  6. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@Nucleus map + MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map + PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@Nucleus map → map BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@Nucleus map
  2. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map + CTIP*|​emp@Nucleus map + WRN@Nucleus map → map ATM|​S1981_pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​MRE11*:​NBS1*|​S343_pho:​RAD50:​WRN@Nucleus map
  3. FANCD2|​K561_ubi|​pho@Nucleus map + MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map + ATR|​pho|​active@Nucleus map → map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
  4. MRE11*@Nucleus map + RAD50@Nucleus map + NBS1*|​S343_pho@Nucleus map → map MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
  5. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map + H2AFX|​S139_pho|​ubi:​MDC1|​pho@Nucleus map → map ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
  6. ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@Nucleus map + MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map → map ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
  7. rc_s4501 → map RAD50@Site of DNA damage map + MRE11*@Site of DNA damage map + NBS1*@Site of DNA damage map
  8. NBS1*@Nucleus map + MRE11*@Nucleus map + RAD50@Nucleus map → map rc_s4501
As Catalyser:
  1. gA_NHEJ_DNA_st1*@Nucleus map → map gA_NHEJ_DNA_st2*@Nucleus map
  2. gHR_DNA_st1*@Nucleus map → map gHR_DNA_st2*@Nucleus map
  3. G1 phase@Nucleus map → map S phase@Nucleus map
  4. S phase@Nucleus map → map G2 phase@Nucleus map
  5. G2 phase@Nucleus map → map M phase@Nucleus map
  6. gFanconi_DNA_st2*@Nucleus map → map gFanconi_DNA_st3*@Nucleus map
  7. gFanconi_DNA_st3*@Nucleus map → map gFanconi_DNA_st4*@Nucleus map
  8. gFanconi_DNA_st4*@Nucleus map → map gHR_DNA_st2*@Nucleus map
  9. FANCD2@Nucleus map → map FANCD2|​pho@Nucleus map
  10. gSSA_DNA_st1*@Nucleus map → map gSSA_DNA_st2*@Nucleus map
  11. ATM@Nucleus map → map ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@Nucleus map
  12. CHEK2@Nucleus map → map CHEK2|​pho|​active@Nucleus map
  13. Ku70*@Nucleus map + Ku80*@Nucleus map → map Ku70*:​Ku80*@Nucleus map
  14. gC_NHEJ_DNA_st1*@Nucleus map → map gC_NHEJ_DNA_st2*@Nucleus map
  15. DNA-PK*@Nucleus map → map DNA-PK*|​pho@Nucleus map
  16. H2AFX@Nucleus map → map H2AFX|​S139_pho@Nucleus map