Reaction heterodimer_association ce_re206 map

FANCD2|​K561_ubi|​pho@Nucleus map + MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map + ATR|​pho|​active@Nucleus map → ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map

Reaction regulators:
Physical_stimulation
  1. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@Nucleus map


References
Phosphorylation of NBS1 bt ATR in responce to crosslink-activation of S phase checkpoint
PMID:15136767
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop cell cycle propagation:
PMID:14988723