Protein Ku80* map

Identifiers
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
HUGO:XRCC5, HGNC:12833,ENTREZ:7520, UNIPROT:P13010

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / C_NHEJ  map

References
PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371,
PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869,
PMID:19772495, PMID:24050180
Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ
PMID:17088286

Ku80*|​ubi@Nucleus

References
ce_re129( Cell Cycle DNA Repair  map ):
PMID:18809224
Complex RNF8:MDC1 ubiquitinates Ku80 and causes it's dissociation from DNA and degradation.This bring to shift from C_NHEJ to HR:
PMID:18001825, PMID:18678709

Ku80*@Nucleus

References
ce_re85:( Cell Cycle DNA Repair  map ) PMID:9242410

Modifications:
In compartment: Nucleus
  1. Ku80*@Nucleus map
  2. Ku80*|​ubi@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. Ku70*:​Ku80*@Nucleus map
  2. Ku70*:​Ku80*:​Securin*@Nucleus map
  3. DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map
  4. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map
  5. APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. Ku80*@Nucleus map → map Ku80*|​ubi@Nucleus map
  2. Ku80*|​ubi@Nucleus map → map degraded
  3. Ku70*:​Ku80*@Nucleus map + Securin*@Nucleus map → map Ku70*:​Ku80*:​Securin*@Nucleus map
  4. Ku80*@Nucleus map + Ku70*@Nucleus map + WRN@Nucleus map + DNA-PK*@Nucleus map → map DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map
  5. Ku70*@Nucleus map + Ku80*@Nucleus map → map Ku70*:​Ku80*@Nucleus map
  6. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@Nucleus map + LIG4:​XLF*:​XRCC4|​hm2@Nucleus map + PARP3@Nucleus map + DNA-PK*|​hm2|​active@Nucleus map + Ku80*@Nucleus map + Ku70*@Nucleus map + APLF@Nucleus map → map APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map
  7. DNA-PK*|​hm2|​active@Nucleus map + Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@Nucleus map + Ku70*:​Ku80*@Nucleus map + PARP3@Nucleus map → map Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map
As Catalyser:
  1. gA_NHEJ_DNA_st1*@Nucleus map → map gA_NHEJ_DNA_st2*@Nucleus map
  2. gC_NHEJ_DNA_st1*@Nucleus map → map gC_NHEJ_DNA_st2*@Nucleus map
  3. gC_NHEJ_DNA_st3*@Nucleus map → map gC_NHEJ_DNA_st4*@Nucleus map
  4. gC_NHEJ_DNA_st4*@Nucleus map → map gC_NHEJ_DNA_st5*@Nucleus map