Identifiers
protein kinase, DNA-activated, catalytic polypeptide
HUGO:PRKDC, HGNC:9413, ENTREZ:5591, UNIPROT:Q9UME3
HUGO:PRKDC HGNC:9413 ENTREZ:5591 UNIPROT:P78527
Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / C_NHEJ
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
References
PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:21376743
PMID:21300785, PMID:21175350, PMID:20691907
synonym:DNAPK
References
ce_re82:( Cell Cycle DNA Repair ) PMID:21376743
References
ce_re85:( Cell Cycle DNA Repair ) PMID:9242410
ce_re95:( Cell Cycle DNA Repair ) PMID:11955432, PMID:19772495
ce_re132:( Cell Cycle DNA Repair ) PMID:19841479, PMID:19793861
ce_re383:( Cell Cycle DNA Repair ) PMID:9892021
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
References
rc_re1046( Regulated Cell Death ):
PMID:12234250
in G361 human melanoma cells, upon ionizing radiations
in vitro by ATM and DNAPK
in Hela, ectopically expressed LKB1 T366-phosphorylated is located in the nucleus
PMID:20160076
in HeLa S3 cells that lack functional LKB1, reexpression of wild-type but not T366A LKB1 restored the ability to repress mTORC1 in response to H2O2
in MCF7, LKB1 is located in the cytoplasm, together with a proportion of ATM. H2O2 induces phosphorylation of cytoplasmic LKB1, but not other DNA damaging agents (etoposide). This supports a possible H2O2-induced and DNA damage-independent activation of the cytoplasmic of ATM responsible for LKB1 phosphorylation.
rc_re1401:( Regulated Cell Death ) PMID:19203584
+ Ku70*@Nucleus + WRN@Nucleus + DNA-PK*@Nucleus → DNA-PK*:Ku70*:Ku80*:WRN@Nucleus
→ DNA-PK*|pho@Nucleus
→ DNA-PK*|hm2|active@Nucleus
+ LIG4:XLF*:XRCC4|hm2@Nucleus + PARP3@Nucleus + DNA-PK*|hm2|active@Nucleus + Ku80*@Nucleus + Ku70*@Nucleus + APLF@Nucleus → APLF:Artemis*|S645_pho|S385_pho|S516_pho|S518_pho:DNA-PK*|hm2:Ku70*:Ku80*:LIG4:PARP3:XLF*:XRCC4|hm2@Nucleus
+ Artemis*|S645_pho|S385_pho|S516_pho|S518_pho|active@Nucleus + Ku70*:Ku80*@Nucleus + PARP3@Nucleus → Artemis*|S645_pho|S385_pho|S516_pho|S518_pho:DNA-PK*|hm2:Ku70*:Ku80*:PARP3@Nucleus
→ DNA-PK*|unk@Nucleus
→ cleaved~DNA-PK*@Nucleus
→ gA_NHEJ_DNA_st2*@Nucleus
→ SMARCAL1|pho@Nucleus
→ Securin*|S165_pho@Nucleus
→ RPA2|pho@Nucleus
→ gC_NHEJ_DNA_st4*@Nucleus
→ DNA-PK*|pho@Nucleus
→ H2AFX|S139_pho@Nucleus
→ Artemis*|S645_pho|S385_pho|S516_pho|S518_pho|active@Nucleus
→ gC_NHEJ_DNA_st5*@Nucleus
→ STK11|K48_unk|T366_pho@Nucleus
→ Caspase2*|S122_pho@Nucleus