Identifiers
NAME:Ku70*:Ku80*
Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / C_NHEJ
References
The complex presents in double amount to cover both ends of broken DNA double helix
Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ
PMID:17088286
ce_re79:( Cell Cycle DNA Repair ) PMID:19772495
ce_re80( Cell Cycle DNA Repair ):
The complex MRN:BRCA1:phos-Ub-CtIP is central in the shift toward HR, because it activates resection for HR and blocks Ku70/80 of C_NHEJ:
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
ce_re95:( Cell Cycle DNA Repair ) PMID:11955432, PMID:19772495
ce_re105( Cell Cycle DNA Repair ):
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737
ce_re374( Cell Cycle DNA Repair ):
PMID:17962814
Link between spindle checkpoint and ds break DNA repair pathway (C_NHEJ)
+ Securin*@Nucleus → Ku70*:Ku80*:Securin*@Nucleus
+ Ku80*@Nucleus → Ku70*:Ku80*@Nucleus
+ Artemis*|S645_pho|S385_pho|S516_pho|S518_pho|active@Nucleus + Ku70*:Ku80*@Nucleus + PARP3@Nucleus → Artemis*|S645_pho|S385_pho|S516_pho|S518_pho:DNA-PK*|hm2:Ku70*:Ku80*:PARP3@Nucleus