Reaction state_transition ce_re36 map

ATM@Nucleus map → ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@Nucleus map

Reaction regulators:
Boolean_logic_gate_and
  1. MLH1:​PMS2@Nucleus map and MSH2|​pho:​MSH6|​pho@Nucleus map
Catalysis
  1. CDK5@Nucleus map
  2. ATM@Nucleus map
Modulation
  1. MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
  2. PPP5C@Nucleus map
  3. ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
Physical_stimulation
  1. MSH2|​pho:​MSH6|​pho@Nucleus map
  2. MLH1:​PMS2@Nucleus map
Trigger
  1. gC_NHEJ_DNA_st1*@Nucleus map
  2. gHR_DNA_st1*@Nucleus map
  3. gFanconi_DNA_st1*@Nucleus map
  4. gA_NHEJ_DNA_st1*@Nucleus map


References
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707