Protein EXO1 map

Identifiers
HUGO:EXO1
exonuclease 1
HUGO:EXO1, HGNC:3511, ENTREZ:9156, UNIPROT:Q9UQ84

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / MMR  map
 Cell Cycle DNA Repair  map  / A_NHEJ  map
 Cell Cycle DNA Repair  map  / HR  map

References
PMID:14676842, PMID:15474417, PMID:18756267, PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:19490890, PMID:11438669, PMID:20019063, PMID:18048416

EXO1@Nucleus

References
te_re40:( Telomere Maintenance  map ) PMID:25845889

EXO1|​S692_pho|​S372_pho|​S567_pho|​S587_pho@Nucleus

References
ce_re71( Cell Cycle DNA Repair  map ):
For inactivation of EXO1 by 53BP1-mediated phosphorylation:
PMID:18756267, PMID:15867354
ATM and ATR phosphorylate EXO1 and lead to EXO1 ubiquitination and degradation:
PMID:18048416, PMID:11438669, PMID:20019063

Modifications:
In compartment: Nucleus
  1. EXO1@Nucleus map
  2. EXO1|​S692_pho|​S372_pho|​S567_pho|​S587_pho@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. BLM:​EXO1@Nucleus map
  2. EXO1:​PCNA:​RFC*:​hMutL*:​hMutS*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. ce_s2743 + ce_s834 + EXO1@Nucleus map + RPA1:​RPA2:​RPA3@Nucleus map + PCNA@Nucleus map + RFC*@Nucleus map → map EXO1:​PCNA:​RFC*:​hMutL*:​hMutS*@Nucleus map
  2. EXO1@Nucleus map + BLM@Nucleus map → map BLM:​EXO1@Nucleus map
  3. EXO1@Nucleus map → map EXO1|​S692_pho|​S372_pho|​S567_pho|​S587_pho@Nucleus map
  4. EXO1|​S692_pho|​S372_pho|​S567_pho|​S587_pho@Nucleus map → map degraded
As Catalyser:
  1. gA_NHEJ_DNA_st1*@Nucleus map → map gA_NHEJ_DNA_st2*@Nucleus map
  2. gHR_DNA_st1*@Nucleus map → map gHR_DNA_st2*@Nucleus map
  3. gSSA_DNA_st1*@Nucleus map → map gSSA_DNA_st2*@Nucleus map
  4. gMMR_DNA_st2*@Nucleus map → map gMMR_DNA_st3*@Nucleus map
  5. gResected_telomeric_DNA*@Nucleus map → map gProcessed_replicated_telomeric_DNA*@Nucleus map