STK11

Protein STK11

Identifiers
serine/threonine kinase 11
HUGO:STK11 HGNC:11389 ENTREZ:6794 UNIPROT:Q15831

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / CASPASES
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / FATTY_ACID_BIOSYNTHESIS
Regulated Cell Death / MITOCHONDRIAL_METABOLISM

References
synonym:LKB1PMID:19037093
PMID:20484410

STK11|K48_ace|T366_unk@Nucleus

References
rc_re468:( Regulated Cell Death ) PMID:18687677

STK11|T366_unk@Nucleus

References
rc_re469:( Regulated Cell Death ) PMID:18687677
rc_re1047:( Regulated Cell Death ) reactionType:is.a

STK11|K48_unk|T366_pho@Nucleus

References
rc_re1046( Regulated Cell Death ):
PMID:12234250
in G361 human melanoma cells, upon ionizing radiations
in vitro by ATM and DNAPK
in Hela, ectopically expressed LKB1 T366-phosphorylated is located in the nucleus
PMID:20160076
in HeLa S3 cells that lack functional LKB1, reexpression of wild-type but not T366A LKB1 restored the ability to repress mTORC1 in response to H2O2
in MCF7, LKB1 is located in the cytoplasm, together with a proportion of ATM. H2O2 induces phosphorylation of cytoplasmic LKB1, but not other DNA damaging agents (etoposide). This supports a possible H2O2-induced and DNA damage-independent activation of the cytoplasmic of ATM responsible for LKB1 phosphorylation.
rc_re1048:( Regulated Cell Death ) reactionType:is.a

STK11|K48_unk@Nucleus

STK11|K48_unk|T366_unk|active@Nucleus

References
rc_re1047:( Regulated Cell Death ) reactionType:is.a
rc_re467:( Regulated Cell Death ) PMID:18687677

STK11@Nucleus

References
rc_re1516:( Regulated Cell Death ) reactionType:is.a

STK11|K48_unk|T366_unk|active@Cytosol

References
rc_re334( Regulated Cell Death ):
PMID:15509864
review
PMID:16054095
by CAMKK2
PMID:16054096
PMID:17244528
by calcium via CAMKK2 and AMPK
PMID:15980064
by CAMKK
PMID:18692468
propose that SESN2 promotes AMPK autophosphorylation, thus increasing TSC1/2 activity.
PMID:19197243
in RPE1-hTERT mouse inner medullary collecting duct cells, in MEFs, in MCF10A, by TAK1, upon TRAIL exposure
in MCF10A upon Ca2+ by CAMKK2
High Calcium lvl activate CAMKK2 enzyme and leads to AMPK activation
PMID:19037093PMID:17244528
PMID:20484410

Modifications:
In compartment: Cytosol

STK11|K48_unk|T366_unk|active@Cytosol

In compartment: Nucleus

STK11@Nucleus
STK11|K48_unk@Nucleus
STK11|T366_unk@Nucleus
STK11|K48_ace|T366_unk@Nucleus
STK11|K48_unk|T366_pho@Nucleus
STK11|K48_unk|T366_unk|active@Nucleus

Participates in complexes:
In compartment: Cytosol

CAB39:STK11|K48_unk|T366_unk|active:STRADA@Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: