Protein MDC1 map

Identifiers
mediator of DNA-damage checkpoint 1
HUGO:MDC1, HGNC:21163, ENTREZ:9656, UNIPROT:Q2TAZ4
HUGO:MDC1 HGNC:21163 ENTREZ:9656 UNIPROT:Q14676

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / S_PHASE_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / C_NHEJ  map
 Cell Cycle DNA Repair  map  / HR  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map

References
PMID:18006705, PMID:17303408, PMID:18583988, PMID:18590585, PMID:17660363, PMID:7575488, PMID:15279786
For S-phase checkpoint
PMID:15459660, PMID:12607003, PMID:18583988, PMID:9407949, PMID:18678890

MDC1@Nucleus

References
ce_re148( Cell Cycle DNA Repair  map ):
PMID:18006705
PMID:18583988

MDC1|​pho@Nucleus

References
ce_re148( Cell Cycle DNA Repair  map ):
PMID:18006705
PMID:18583988
ce_re149:( Cell Cycle DNA Repair  map ) PMID:17303408, PMID:16377563

MDC1|​T752_pho|​T699_pho|​T719_pho|​Nter-SDT-motifs_pho@Site of DNA damage

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map

References
rc_re1480( Regulated Cell Death  map ):
PMID:18001824
PMID:18006705
rc_re1481:( Regulated Cell Death  map ) reactionType:is.a
rc_re1501( Regulated Cell Death  map ):
influenceDelete: re to products
PMID:18087291
review
rc_re1503( Regulated Cell Death  map ):
influenceDelete: re to reactants

MDC1|​T752_don|​T699_don|​T719_don|​Nter-SDT-motifs_pho@Site of DNA damage

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map

References
rc_re1481:( Regulated Cell Death  map ) reactionType:is.a
rc_re1478( Regulated Cell Death  map ):
influenceDelete: re to products
PMID:18087291
review, more specifically retention of NBN
PMID:18001824
NBN interacts even with MDC1 mutated on its 3 phosphoacceptor sites

MDC1|​Nter-SDT-motifs_pho@Site of DNA damage

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map

References
rc_re1479( Regulated Cell Death  map ):
PMID:16377563
PMID:16049003
rc_re1480( Regulated Cell Death  map ):
PMID:18001824
PMID:18006705
rc_re1482:( Regulated Cell Death  map ) reactionType:is.a

MDC1|​Nter-SDT-motifs_pho@Nucleus

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map

References
rc_re1483:( Regulated Cell Death  map ) PMID:18411308
rc_re1479( Regulated Cell Death  map ):
PMID:16377563
PMID:16049003

Modifications:
In compartment: Nucleus
  1. MDC1@Nucleus map
  2. MDC1|​pho@Nucleus map
  3. MDC1|​Nter-SDT-motifs_pho@Nucleus map
In compartment: Site of DNA damage
  1. MDC1|​Nter-SDT-motifs_pho@Site of DNA damage map
  2. MDC1|​T752_don|​T699_don|​T719_don|​Nter-SDT-motifs_pho@Site of DNA damage map
  3. MDC1|​T752_pho|​T699_pho|​T719_pho|​Nter-SDT-motifs_pho@Site of DNA damage map
Participates in complexes:
In compartment: Nucleus
  1. MDC1|​pho:​RNF8@Nucleus map
  2. H2AFX|​S139_pho|​ubi:​MDC1|​pho@Nucleus map
  3. ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. MDC1@Nucleus map → map MDC1|​pho@Nucleus map
  2. H2AFX|​S139_pho|​ubi@Nucleus map + MDC1|​pho@Nucleus map → map H2AFX|​S139_pho|​ubi:​MDC1|​pho@Nucleus map
  3. RNF8@Nucleus map + MDC1|​pho@Nucleus map → map MDC1|​pho:​RNF8@Nucleus map
  4. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map + H2AFX|​S139_pho|​ubi:​MDC1|​pho@Nucleus map → map ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
  5. MDC1|​Nter-SDT-motifs_pho@Nucleus map → map MDC1|​Nter-SDT-motifs_pho@Site of DNA damage map
  6. MDC1|​Nter-SDT-motifs_pho@Site of DNA damage map → map MDC1|​T752_pho|​T699_pho|​T719_pho|​Nter-SDT-motifs_pho@Site of DNA damage map
  7. MDC1|​T752_pho|​T699_pho|​T719_pho|​Nter-SDT-motifs_pho@Site of DNA damage map → map MDC1|​T752_don|​T699_don|​T719_don|​Nter-SDT-motifs_pho@Site of DNA damage map
  8. MDC1|​Nter-SDT-motifs_pho@Site of DNA damage map → map MDC1|​T752_don|​T699_don|​T719_don|​Nter-SDT-motifs_pho@Site of DNA damage map
  9. MDC1@Nucleus map → map MDC1|​Nter-SDT-motifs_pho@Nucleus map
As Catalyser:
  1. gHR_DNA_st1*@Nucleus map → map gHR_DNA_st2*@Nucleus map
  2. S phase@Nucleus map → map G2 phase@Nucleus map
  3. G2 phase@Nucleus map → map M phase@Nucleus map
  4. Ku80*@Nucleus map → map Ku80*|​ubi@Nucleus map
  5. gHR_DNA_st2*@Nucleus map → map gHR_DNA_st3*@Nucleus map
  6. H2AFX|​S139_pho@Nucleus map → map H2AFX|​S139_pho|​ubi@Nucleus map
  7. ATM@Nucleus map → map ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@Nucleus map
  8. CHEK2@Nucleus map → map CHEK2|​pho|​active@Nucleus map
  9. Ku70*@Nucleus map + Ku80*@Nucleus map → map Ku70*:​Ku80*@Nucleus map
  10. DNA-PK*@Nucleus map → map DNA-PK*|​pho@Nucleus map
  11. NBS1*@Site of DNA damage map → map NBS1*@Nucleus map
  12. TP53BP1@Site of DNA damage map → map TP53BP1@Site of DNA damage map
  13. BRCA1@Site of DNA damage map → map BRCA1@Nucleus map
  14. RNF8@Nucleus map → map RNF8@Site of DNA damage map