Identifiers
TAO kinase 1
HUGO:TAOK1 HGNC:29259 ENTREZ:57551 UNIPROT:Q7L7X3
TAO kinase 2
HUGO:TAOK2 HGNC:16835 ENTREZ:9344 UNIPROT:Q9UL54
TAO kinase 3
HUGO:TAOK3 HGNC:18133 ENTREZ:51347 UNIPROT:Q9H2K8
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
TAO kinases are novel MAP3Ks that specifically regulate P38s.
Ataxia telangiectasia mutated (ATM) is activated in response to DNA damage and directly phosphorylates TAOK.
PMID:11274345 PMID:18855897
References
su_mpk1_mpk1_re255( Survival ):
Ataxia telangiectasia mutated (ATM) is activated in response to DNA damage and directly phosphorylates TAOK.
PMID:18855897
References
su_mpk1_mpk1_re255( Survival ):
Ataxia telangiectasia mutated (ATM) is activated in response to DNA damage and directly phosphorylates TAOK.
PMID:18855897
su_mpk1_mpk1_re153( Survival ):
MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner.
MEKK2 and MEKK3 can activate JNK P38 and ERK pathways.
TAO kinases are novel MAP3Ks that specifically regulate P38s.
ASK1 is a MAP3K and can activate both JNK and P38 pathways.
MEKK1 selectively activates the endogenous JNK pathway. MEKK1 can activate MEK4 and MEK7 in vivo.
MEKK4 is a MAP3K and can activate both JNK and P38 pathways.
TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways.
Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6.
MLK3 has the potential to positively regulate the ERK / MAPK pathway by directly phosphorylating and activating MEK.
Expression of GADD45 genes in mammalian cells strongly activates co-expressed MTK1 as well as P38 and JNK the MAPKs downstream of MTK1. TAO kinases are MAP3Ks that function upstream of P38 and JNK.
PMID:11274345 PMID:12738796 PMID:18855897 PMID:21614932