Identifiers
poly (ADP-ribose) polymerase 1
HUGO:PARP1, HGNC:270, ENTREZ:142, P09874
HUGO:PARP1 HGNC:270 ENTREZ:142 UNIPROT:P09874

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair   / G1_S_CHECKPOINT 
 Cell Cycle DNA Repair   / S_PHASE_CHECKPOINT 
 Cell Cycle DNA Repair   / G2_M_CHECKPOINT 
 Cell Cycle DNA Repair   / BER 
 Cell Cycle DNA Repair   / HR 
 Cell Cycle DNA Repair   / C_NHEJ 
 Cell Cycle DNA Repair   / A_NHEJ 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / PARTHANATOS 

References
NOTE:
PARP-? poly-ADP-ribosilated
PMID:22055391
PARP is active phosphorylated and poly-ADP-ribosilated form
PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072
PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce
PMID:22921416
PARP3 activated spindle checkpoint and binds to double strand breaks together with PAPRP1
PMID:21270334
PARPs in cellular functions
PMID:22713970
PARP1 in chromatin remodeling
PMID:22469522, PMID:22713970
PARP1 initiating A_NHEJ (alt_NHEJ)
PMID:24050180
PMID:19364882
For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ):
PMID:21376743
PMID:22743550
PMID:23562323
PMID:24210699
Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ
PMID:17088286
PMID:23145148
PMID:23568489
PMID:17116881
PMID:24684389
PARP-1 becomes overactivated and produces toxic
levels of PAR, which translocates to the cytosol, from where it
signals to AIF to effect its nuclear translocation
PMID:24976506

References
ce_re555( Cell Cycle DNA Repair  ):
Triple phosphorylation by CDK5 inhibits PARP1
PMID:21922195

References
ce_re555( Cell Cycle DNA Repair  ):
Triple phosphorylation by CDK5 inhibits PARP1
PMID:21922195

References
ce_re105( Cell Cycle DNA Repair  ):
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737

1. PARP1@Nucleus
2. PARP1|​PolyADPribose_unk|​pho@Nucleus
3. PARP1|​Ser782_pho|​Ser786_pho|​Ser785_pho@Nucleus

1. H2AFX:​PARP1@Nucleus
2. CIP1_KIP1*:​PARP1@Nucleus
3. PARP1|​PolyADPribose_unk|​pho:​PARP3@Nucleus
4. PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@Nucleus
5. LIG1:​PARP1|​PolyADPribose_unk|​pho:​PCNA@Nucleus
6. LIG3:​PARP1|​PolyADPribose_unk|​pho:​XRCC1|​pho@Nucleus
7. PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@Nucleus
8. PARP1:​PCNA:​POLB:​POLD*:​POLE*:​RFC*@Nucleus
9. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@Nucleus

1. POLB@Nucleus + PCNA@Nucleus + POLE*@Nucleus + POLD*@Nucleus + PARP1|​PolyADPribose_unk|​pho@Nucleus + RFC*@Nucleus → PARP1:​PCNA:​POLB:​POLD*:​POLE*:​RFC*@Nucleus
2. XRCC1|​pho@Nucleus + LIG3@Nucleus + PARP1|​PolyADPribose_unk|​pho@Nucleus → LIG3:​PARP1|​PolyADPribose_unk|​pho:​XRCC1|​pho@Nucleus
3. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@Nucleus + MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus + PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@Nucleus → BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@Nucleus
4. POLB@Nucleus + XRCC1|​pho@Nucleus + PARP1|​PolyADPribose_unk|​pho@Nucleus + WRN|​ace@Nucleus + PNK*@Nucleus → PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@Nucleus
5. PCNA@Nucleus + LIG1@Nucleus + PARP1|​PolyADPribose_unk|​pho@Nucleus → LIG1:​PARP1|​PolyADPribose_unk|​pho:​PCNA@Nucleus
6. PARP1@Nucleus → PARP1|​PolyADPribose_unk|​pho@Nucleus
7. PARP1|​PolyADPribose_unk|​pho@Nucleus → PARP1@Nucleus
8. H2AFX@Nucleus + PARP1|​PolyADPribose_unk|​pho@Nucleus → H2AFX:​PARP1@Nucleus
9. p53*@Nucleus + PARP1|​PolyADPribose_unk|​pho@Nucleus → ce_s2572
10. CIP1_KIP1*@Nucleus + PARP1|​PolyADPribose_unk|​pho@Nucleus → CIP1_KIP1*:​PARP1@Nucleus
11. PARP1|​PolyADPribose_unk|​pho@Nucleus → Oxidative stress@Nucleus
12. PARP1|​PolyADPribose_unk|​pho@Nucleus → Mitochondria metabolism@Nucleus
13. PARP2|​unk|​pho@Nucleus + PARP1|​PolyADPribose_unk|​pho@Nucleus → PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@Nucleus
14. PARP3@Nucleus + PARP1|​PolyADPribose_unk|​pho@Nucleus → PARP1|​PolyADPribose_unk|​pho:​PARP3@Nucleus
15. PARP1@Nucleus → PARP1|​Ser782_pho|​Ser786_pho|​Ser785_pho@Nucleus
16. PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@Nucleus → Telomere maintenance@Nucleus
17. PARP1|​PolyADPribose_unk|​pho@Nucleus → Chromatin remodeling@Nucleus

1. gA_NHEJ_DNA_st1*@Nucleus → gA_NHEJ_DNA_st2*@Nucleus
2. gHR_DNA_st1*@Nucleus → gHR_DNA_st2*@Nucleus
3. G1 phase@Nucleus → S phase@Nucleus
4. gA_NHEJ_DNA_st5*@Nucleus → gA_NHEJ_DNA_st6*@Nucleus
5. gHR_DNA_st6*@Nucleus → gHR_DNA_st7*@Nucleus
6. gShP_BER_M-glyc_st5_B-glyc_DNA_st5*@Nucleus → gShP_BER_M-glyc_st5_B-glyc_DNA_st6*@Nucleus
7. gLnP_BER_M-glyc_st5*@Nucleus → gLnP_BER_M-glyc_st6*@Nucleus
8. gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + dNTPs@Nucleus → gShP_BER_M-glyc_st5_B-glyc_DNA_st5*@Nucleus
9. gBER_M-glyc_DNA_st3*@Nucleus + dNTPs@Nucleus → gLnP_BER_M-glyc_st4*@Nucleus
10. SNAI1@Nucleus → SNAI1|​unk@Nucleus
11. WRN@Nucleus → WRN|​unk@Nucleus
12. gSingle_strand_breaks_SSB*@Nucleus → gBER_B-glyc_DNA_st3*@Nucleus
13. gSingle_strand_breaks_SSB*@Nucleus → gBER_M-glyc_DNA_st3*@Nucleus
14. gC_NHEJ_DNA_st1*@Nucleus → gC_NHEJ_DNA_st2*@Nucleus