Identifiers
HUGO:MDM2
Mdm2 p53 binding protein homolog (mouse)
HUGO:MDM2, HGNC:6973, ENTREZ:4193, UNIPROT:Q00987
HUGO:MDM2, HGNC:6973, ENTREZ:4193, UNIPROT:Q13301
MDM2 oncogene, E3 ubiquitin protein ligase
"Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein"
HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2
Mdm2 p53 binding protein homo

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / SENESCENCE 
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair   / G2_M_CHECKPOINT 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DNA_DAMAGE_RESPONSE 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / RCD_GENES 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / MAPK 
 Survival   / PI3K_AKT_MTOR 
 Survival   / WNT_NON_CANONICAL 

References
MDM2 = ubiquitin-ligase, regulates p53 stability: induce its degradation via the proteasome.
PMID:15024084
PMID:14761977, PMID:11779693, PMID:17110379, PMID:9450543, PMID:15876864
The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity.
PMID:17158541
PMID:20679392
PMID:15169778
PMID:11923280
PMID:11715018

References
mo_re5:( motility  ) PMID:21084277 PMID:19945467
mo_re6:( motility  ) PMID:21084277 PMID:19945467 PMID:29435006

References
mo_re5:( motility  ) PMID:21084277 PMID:19945467

References
em_emtc_emtc_re1210( EMT Senescence  ):
MDM2 phosphorylation by ATM inhibits its interaction with p53
PMID:15140942
Phosphorylation at Ser395
PMID:11331603

References
em_emtc_emtc_re1213( EMT Senescence  ):
PMID:15140942
Phosphorylations on p53 prevent its binding to MDM2.
PMID:15574337
S186 phosphorylation of MDM2 by AKT favors the binding of MDM2 to p53 and its following degradation.
PMID:19336515
TWIST1 physically promotes interaction between p53 and MDM2

References
em_emtc_emtc_re1210( EMT Senescence  ):
MDM2 phosphorylation by ATM inhibits its interaction with p53
PMID:15140942
Phosphorylation at Ser395
PMID:11331603

References
ce_re49:( Cell Cycle DNA Repair  ) PMID:19788416

References
s_akt1_re118( Survival  ):
PMID:15169778
PMID:11923280
PMID:11715018
PMID:16697215

References
s_akt1_re118( Survival  ):
PMID:15169778
PMID:11923280
PMID:11715018
PMID:16697215

References
s_akt1_re120( Survival  ):
PMID:15169778
PMID:11923280
PMID:11715018

References
s_akt1_re119( Survival  ):
PMID:15169778
PMID:11923280
PMID:11715018

References
s_akt2_re66:( Survival  ) PMID15169778
s_akt2_re68:( Survival  ) PMID:15169778 PMID:10722742

References
s_akt2_re66:( Survival  ) PMID15169778
s_akt2_re68:( Survival  ) PMID:15169778 PMID:10722742
s_akt2_re70( Survival  ):
PMID:10721693
PMID:19459846

References
s_akt2_re68:( Survival  ) PMID:15169778 PMID:10722742

References
s_akt2_re75:( Survival  ) PMID:19321440
s_akt2_re127:( Survival  ) PMID:15084260
s_wnc2_re72( Survival  ):
Where exactly MDM2 ubiquitinates NFAT is not known and also not known if it is in the cytosol or nucleus.
PMID:16307918

1. MDM2@Cytoplasm
2. MDM2@Cytoplasm
3. MDM2|​S166_emp@Cytoplasm
4. MDM2|​S166_pho|​pho@Cytoplasm

1. MDM2@Cytosol
2. MDM2|​pho|​active@Cytosol

1. MDM2@Nucleus
2. MDM2|​pho@Nucleus
3. MDM2|​S186_pho@Nucleus
4. MDM2|​S395_pho@Nucleus
5. MDM2|​pho|​pho@Nucleus
6. MDM2|​S166_pho|​pho@Nucleus
7. MDM2|​pho|​pho|​pho@Nucleus
8. MDM2|​pho|​pho|​ubi@Nucleus
9. MDM2|​S166_pho|​pho|​S188_pho@Nucleus

1. MDM2|​S186_pho:​p53*@Cytosol

1. MDM2|​S186_pho:​p53*@Nucleus
2. MDM2|​S186_pho:​SNAI2:​p53*@Nucleus

1. MDM2@Nucleus → MDM2|​pho@Nucleus
2. MDM2|​pho@Nucleus → degraded
3. MDM2@Nucleus → MDM2|​S395_pho@Nucleus
4. MDM2@Nucleus → MDM2|​S186_pho@Nucleus
5. p53*@Nucleus + MDM2|​S186_pho@Nucleus → MDM2|​S186_pho:​p53*@Nucleus
6. MDM2|​S186_pho:​p53*@Nucleus → MDM2|​S186_pho:​p53*@Cytosol
7. MDM2|​S186_pho:​p53*@Cytosol → degraded
8. SNAI2@Nucleus + MDM2|​S186_pho:​p53*@Nucleus → MDM2|​S186_pho:​SNAI2:​p53*@Nucleus
9. MDM2|​S186_pho:​SNAI2:​p53*@Nucleus → degraded
10. rMDM2@Nucleus → MDM2@Nucleus
11. MDM2|​S186_pho:​p53*@Nucleus → degraded
12. MDM2@Cytosol → MDM2|​pho|​active@Cytosol
13. rMDM2@Nucleus → MDM2@Cytosol
14. MDM2|​S166_emp@Cytoplasm → MDM2|​S166_pho|​pho@Cytoplasm
15. MDM2|​S166_pho|​pho@Nucleus → MDM2|​S166_pho|​pho|​S188_pho@Nucleus
16. MDM2|​S166_pho|​pho@Cytoplasm → MDM2|​S166_pho|​pho@Nucleus
17. MDM2|​pho|​pho@Nucleus → MDM2|​pho|​pho|​pho@Nucleus
18. MDM2|​pho|​pho@Nucleus → MDM2|​pho|​pho|​ubi@Nucleus
19. gMDM2@Nucleus → MDM2@Nucleus

1. p53*@Nucleus → degraded
2. APE*@Nucleus → APE*|​Thr233_pho|​ubi@Nucleus
3. p53*@Cytosol → p53*|​ubi@Cytosol
4. p53*|​S15_pho|​active@Nucleus → p53*@Nucleus
5. FOXO3|​S644_pho@Cytoplasm → FOXO3|​S644_pho|​ubi@Cytoplasm
6. MDM2|​pho|​pho@Nucleus → MDM2|​pho|​pho|​ubi@Nucleus
7. p53*@Nucleus → p53*|​ubi@Nucleus
8. FOXO3|​pho|​pho|​pho@Cytoplasm → FOXO3|​pho|​pho|​pho|​ubi@Cytoplasm
9. p53*@Nucleus → p53*|​ubi|​ubi@Nucleus
10. p53*|​pho@Nucleus → p53*@Nucleus
11. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm → NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​ubi|​ubi@Cytoplasm