Identifiers
PolB, polymerase (DNA directed), beta
HUGO:POLB, HGNC:9174, ENTREZ:5423, UNIPROT:P06746

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair   / BER 

References
PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013
POLB is important for repair of ROS-induced DNA damage, inhibiting impoves sensitivity to ROS-like drugs
PMID:20510258, PMID:21251944

References
ce_re2:( Cell Cycle DNA Repair  ) deoxyribose-phosphatase activity of PolB
ce_re7:( Cell Cycle DNA Repair  ) deoxyribose 5'-phosphatase activity of PolB
ce_re22( Cell Cycle DNA Repair  ):
PMID:18398454
PMID:16449207
RECQL5 activates BER via XRCC1 and PARP1
PMID:22973052

1. POLB@Nucleus

1. PARP2|​unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@Nucleus
2. PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@Nucleus
3. PARP1:​PCNA:​POLB:​POLD*:​POLE*:​RFC*@Nucleus

1. POLB@Nucleus + PCNA@Nucleus + POLE*@Nucleus + POLD*@Nucleus + PARP1|​PolyADPribose_unk|​pho@Nucleus + RFC*@Nucleus → PARP1:​PCNA:​POLB:​POLD*:​POLE*:​RFC*@Nucleus
2. POLB@Nucleus + XRCC1|​pho@Nucleus + PARP1|​PolyADPribose_unk|​pho@Nucleus + WRN|​ace@Nucleus + PNK*@Nucleus → PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@Nucleus
3. PARP2|​unk|​pho@Nucleus + WRN|​ace@Nucleus + PNK*@Nucleus + XRCC1|​pho@Nucleus + POLB@Nucleus → PARP2|​unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@Nucleus

1. gBER_M-glyc_DNA_st3*@Nucleus → gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + 5'dRP@Nucleus
2. gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + dNTPs@Nucleus → gShP_BER_M-glyc_st5_B-glyc_DNA_st5*@Nucleus
3. gBER_M-glyc_DNA_st3*@Nucleus + dNTPs@Nucleus → gLnP_BER_M-glyc_st4*@Nucleus
4. gBER_B-glyc_DNA_st2*@Nucleus → gBER_B-glyc_DNA_st3*@Nucleus