Protein POLH map

Identifiers
polymerase (DNA directed), eta
HUGO:POLH, HGNC:9181, ENTREZ:5429, UNIPROT:Q9Y253

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / TLS  map
 Cell Cycle DNA Repair  map  / HR  map
 Cell Cycle DNA Repair  map  / FANCONI  map

References
PMID:18196958, PMID:17652783
Related to the Y-family polymerases
PMID:19258535
POLH participates in the D-loop formation in HR
PMID:16337602, PMID:16337601
Bypasses thymidine-thymidine (T-T) cyclobutane pyrimidine dimer (CPD) very accurately
PMID:15189446
Cisplatin tolerance in cells with active POLH
PMID:22562137

POLH@Nucleus

References
ce_re139( Cell Cycle DNA Repair  map ):
PMID:19686080
POLH participates in the D-loop formation in HR:
PMID:16337602, PMID:16337601
Complex PolN:HEL308 participates in HR and in Fanconi PMID:19995904
ce_re236( Cell Cycle DNA Repair  map ):
Recruitment of all components as POLH and RAD6/RAD18 that ubiguitinate PCNA all together activate TLS:
PMID:16824193
ce_re252( Cell Cycle DNA Repair  map ):
Requirement for functional DNA polymerase eta in genome-wide repair by NER of UV-induced DNA damage during S phase:
PMID:20457011
Link between Fanconi and NER
PMID:22615860

Modifications:
In compartment: Nucleus
  1. POLH@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. PCNA|​K164_ubi:​POLH:​REV1@Nucleus map
  2. POLH:​RAD18:​RAD6*:​REV1@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. RAD18:​RAD6*@Nucleus map + POLH@Nucleus map + REV1@Nucleus map → map POLH:​RAD18:​RAD6*:​REV1@Nucleus map
  2. REV1@Nucleus map + PCNA|​K164_ubi@Nucleus map + POLH@Nucleus map → map PCNA|​K164_ubi:​POLH:​REV1@Nucleus map
As Catalyser:
  1. gHR_DNA_st3*@Nucleus map → map gHR_DNA_st4*@Nucleus map
  2. gGG-NER_DNA_st1*@Nucleus map → map gGG-NER_DNA_st2*@Nucleus map
  3. gTLS_DNA_st1*@Nucleus map → map gTLS_DNA_st2*@Nucleus map