Protein CLSPN map

Identifiers
Claspin
HUGO:CLSPN, HGNC:19715, ENTREZ:63967, UNIPROT:Q9HAW4
PMID:17303408, PMID:16880517, PMID:16934469

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / S_PHASE_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map

References
For S-phase checkpoint
PMID:15459660, PMID:19793801, PMID:17582221, PMID:18677104, PMID:17384638, PMID:12766152

CLSPN|​pho@Nucleus

References
ce_re463( Cell Cycle DNA Repair  map ):
Arrests cell cycle in S-phase in response to stalled replication fork or ds breaks in DNA:
PMID:15459660, PMID:17384638, PMID:19793801

Modifications:
In compartment: Nucleus
  1. CLSPN@Nucleus map
  2. CLSPN|​pho@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. ATRIP:​ATR|​pho:​CLSPN|​pho@Nucleus map
  2. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@Nucleus map
  3. ATRIP:​ATR|​pho:​CLSPN|​pho:​RAD17|​pho:​TOPBP1@Nucleus map
  4. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​TIM1*:​TIPIN@Nucleus map
  5. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. TOPBP1@Nucleus map + ATRIP:​ATR|​pho@Nucleus map + CLSPN|​pho@Nucleus map + RAD17|​pho@Nucleus map → map ATRIP:​ATR|​pho:​CLSPN|​pho:​RAD17|​pho:​TOPBP1@Nucleus map
  2. ATRIP:​ATR|​pho@Nucleus map + CLSPN|​pho@Nucleus map + RPA1:​RPA2:​RPA3@Nucleus map → map ATRIP:​ATR|​pho:​CLSPN|​pho@Nucleus map
  3. HCLK2*@Nucleus map + CLSPN|​pho@Nucleus map + ATRIP:​ATR|​pho@Nucleus map + CHEK1|​pho|​active@Nucleus map → map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@Nucleus map
  4. TIM1*@Nucleus map + CLSPN|​pho@Nucleus map + PCNA|​K164_ubi@Nucleus map + ATRIP:​ATR|​pho@Nucleus map + CHEK1|​pho|​active@Nucleus map → map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@Nucleus map
  5. CLSPN@Nucleus map → map CLSPN|​pho@Nucleus map
  6. ATRIP:​ATR|​pho:​CLSPN|​pho@Nucleus map + TIPIN@Nucleus map + TIM1*@Nucleus map + CHEK1|​pho|​active@Nucleus map → map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​TIM1*:​TIPIN@Nucleus map
As Catalyser:
  1. S phase@Nucleus map → map G2 phase@Nucleus map
  2. gDamaged_DNA*@Nucleus map → map gRepaired_DNA*@Nucleus map
  3. CHEK1@Nucleus map → map CHEK1|​pho|​active@Nucleus map
  4. ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@Nucleus map + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@Nucleus map + CDT1@Nucleus map + CDC6@Nucleus map + CDC45@Nucleus map + POLA*@Nucleus map + PRIM*@Nucleus map + RPA1@Nucleus map + RPA2@Nucleus map + RPA3@Nucleus map → map CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*@Nucleus map
  5. No DNA replicarion@Nucleus map → map DNA replicarion@Nucleus map
  6. RAD1@Nucleus map + RAD9*|​pho@Nucleus map + HUS1@Nucleus map → map HUS1:​RAD1:​RAD9*|​pho@Nucleus map
  7. HUS1:​RAD1:​RAD9*|​pho@Nucleus map + RAD17@Nucleus map + RFC*@Nucleus map → map HUS1:​RAD1:​RAD17:​RAD9*:​RFC*@Nucleus map