Identifiers
HUGO:CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
HUGO:CDKN1A, HGNC:1784, ENTREZ:1026, GENECARDS:GC06P036649, UNIPROT:P38936??
HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936
CDKN1
HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / SENESCENCE 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / RCD_GENES 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / MAPK 
 Survival   / PI3K_AKT_MTOR 

References
PMID:24954210
p27, p16 and p15 inhibits CDK4_6. This induces a G1 cell cycle arrest.
PMID:19440234
p21 inhibits CDK2 to induce senescence
PMID:10402472
p21 induces metastasis
p21 suppresses E2F1-dependent Wnt4 expression, thereby controlling cellular growth.
synonym:p21 synonym:CIP1 synonym:WAF1
PMID:12851486

References
mo_re45:( motility  ) PMID:18471976 PMID:19945467 PMID:27328425

References
mo_re44:( motility  ) PMID:18471976 PMID:19945467
mo_re45:( motility  ) PMID:18471976 PMID:19945467 PMID:27328425

References
mo_re42:( motility  ) PMID:18471976 PMID:19945467 PMID:27328425

References
su_mpk1_mpk1_re269( Survival  ):
P21 is a direct substrate of AKT and this may regulate the subcellular localisation of P21. Phosphorylation of P21 by AKT correlated with its exit from the nucleus and with increased cell cycle progression.
PMID:11882383

References
s_akt1_re186:( Survival  ) PMID:11756412

References
s_akt1_re186:( Survival  ) PMID:11756412

References
s_akt1_re188:( Survival  ) PMID:11756412
s_akt1_re189:( Survival  ) PMID:19440234

References
s_akt2_re144:( Survival  ) PMID:11463845 PMID:11756412

References
s_akt2_re146:( Survival  ) PMID:11756412

1. p21CIP1*@Cytoplasm
2. p21CIP1*@Cytoplasm
3. p21CIP1*|​pho@Cytoplasm
4. p21CIP1*|​T145_pho@Cytoplasm
5. p21CIP1*|​T145_pho|​T146_pho@Cytoplasm

1. p21CIP1*@Cytosol
2. p21CIP1*|​pho@Cytosol

1. p21CIP1*@Nucleus
2. p21CIP1*|​pho@Nucleus
3. p21CIP1*|​pho|​pho@Nucleus

1. Caspase3*:​p21CIP1*|​T145_pho@Cytoplasm

1. CDK4_6*:​CyclinD1*:​p21CIP1*@Cytosol

1. CyclinD*|​T286_pho:​p21CIP1*|​pho|​pho@Nucleus

1. p21CIP1*@Cytosol + CDK4_6*:​CyclinD1*@Cytosol → CDK4_6*:​CyclinD1*:​p21CIP1*@Cytosol
2. rp21CIP1*@Nucleus → p21CIP1*@Cytosol
3. p21CIP1*@Cytosol → Metastasis@Cytosol
4. rp21CIP1*@Nucleus → p21CIP1*@Nucleus
5. p21CIP1*@Nucleus → p21CIP1*@Cytosol
6. p21CIP1*@Cytosol → p21CIP1*|​pho@Cytosol
7. p21CIP1*@Nucleus → G1 Cell cycle arrest@Nucleus
8. rp21CIP1*@Nucleus → p21CIP1*@Cytosol
9. p21CIP1*@Cytoplasm → p21CIP1*|​T145_pho@Cytoplasm
10. p21CIP1*|​T145_pho@Cytoplasm → p21CIP1*|​T145_pho|​T146_pho@Cytoplasm
11. p21CIP1*|​T145_pho|​T146_pho@Cytoplasm + Caspase3*@Cytoplasm → Caspase3*:​p21CIP1*|​T145_pho@Cytoplasm
12. PCNA@Nucleus + p21CIP1*@Nucleus → su_akt1_s_akt2_s384
13. p21CIP1*@Nucleus → p21CIP1*|​pho@Nucleus
14. p21CIP1*@Cytoplasm → p21CIP1*@Nucleus
15. p21CIP1*|​pho@Nucleus → p21CIP1*|​pho|​pho@Nucleus
16. p21CIP1*|​pho|​pho@Nucleus + CyclinD*|​T286_pho@Nucleus + CDK4_6*@Nucleus → CyclinD*|​T286_pho:​p21CIP1*|​pho|​pho@Nucleus
17. CyclinD*|​T286_pho:​p21CIP1*|​pho|​pho@Nucleus → G1 phase@Nucleus
18. p21CIP1*@Nucleus → p21CIP1*|​pho@Cytoplasm
19. p21CIP1*@Nucleus → Growth arrest@Cytoplasm
20. gp21CIP1*@Nucleus → p21CIP1*@Nucleus

1. Late G1 phase@Cytosol → S phase@Cytosol
2. gCDK2@Nucleus → rCDK2@Nucleus
3. E2F1@Nucleus → E2F1@Nucleus
4. NFE2L2@Cytosol → NFE2L2|​ubi@Cytosol