Protein REV1 map

Identifiers
REV1 homolog (S. cerevisiae)
HUGO:REV1, HGNC:14060, ENTREZ:51455, UNIPROT:Q9UBZ9

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / FANCONI  map
 Cell Cycle DNA Repair  map  / TLS  map

References
PMID:23065650
Related to Y-family polymerases. For Fanconi anemia pathway
PMID:19686080, PMID:19622404, PMID:18931676
For hiperphosphotyration of REV1 in cell cycle and DNA danage-dependent manner.
Hyperphosphorylation makes REV1 regulatory molecule for activating TLS pathway
PMID:17035102, PMID:19258535

REV1|​pho|​pho|​pho@Nucleus

References
ce_re185( Cell Cycle DNA Repair  map ):
For hyper-phosphotyration of REV1 in cell cycle and DNA damage-dependent manner. Hyper-phosphorylation makes REV1 regulatory molecule for activating TLS pathway
PMID:17035102, PMID:19258535
ce_re489( Cell Cycle DNA Repair  map ):
Reaction (id=re180, name=; CellCycle_DNArepair_18_12_2010_Version3.xml)
Phosphorilated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
PMID:17035102
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
PMID:19225445
REV1 interacts with many TLS polymerases:
PMID:14657033
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158
For TLS
PMID:19258535
FA core complex regulates REV1 and activated TLS
PMID:22266823

REV1|​pho@Nucleus

References
ce_re185( Cell Cycle DNA Repair  map ):
For hyper-phosphotyration of REV1 in cell cycle and DNA damage-dependent manner. Hyper-phosphorylation makes REV1 regulatory molecule for activating TLS pathway
PMID:17035102, PMID:19258535

Modifications:
In compartment: Nucleus
  1. REV1@Nucleus map
  2. REV1|​pho@Nucleus map
  3. REV1|​pho|​pho|​pho@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. PCNA|​K164_ubi:​REV1@Nucleus map
  2. PCNA|​K164_ubi:​POLH:​REV1@Nucleus map
  3. PCNA|​K164_ubi:​POLI:​REV1@Nucleus map
  4. PCNA|​K164_ubi:​POLK:​REV1@Nucleus map
  5. POLH:​RAD18:​RAD6*:​REV1@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. PCNA|​K164_ubi@Nucleus map + POLK@Nucleus map + REV1@Nucleus map → map PCNA|​K164_ubi:​POLK:​REV1@Nucleus map
  2. PCNA|​K164_ubi@Nucleus map + POLI@Nucleus map + REV1@Nucleus map → map PCNA|​K164_ubi:​POLI:​REV1@Nucleus map
  3. PCNA|​K164_ubi@Nucleus map + REV1@Nucleus map → map PCNA|​K164_ubi:​REV1@Nucleus map
  4. REV1@Nucleus map → map REV1|​pho@Nucleus map
  5. REV1|​pho@Nucleus map → map REV1|​pho|​pho|​pho@Nucleus map
  6. RAD18:​RAD6*@Nucleus map + POLH@Nucleus map + REV1@Nucleus map → map POLH:​RAD18:​RAD6*:​REV1@Nucleus map
  7. REV1@Nucleus map + PCNA|​K164_ubi@Nucleus map + POLH@Nucleus map → map PCNA|​K164_ubi:​POLH:​REV1@Nucleus map
As Catalyser:
  1. gFanconi_DNA_st4*@Nucleus map → map gFanconi_DNA_st5*@Nucleus map
  2. gTLS_DNA_st1*@Nucleus map → map gTLS_DNA_st2*@Nucleus map