Protein GADD45A map

Identifiers
Growth arrest and DNA-damage-inducible, alpha
HUGO:GADD45A, HGNC:4095, ENTREZ:1647, UNIPROT:P24522

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / NER  map
 Cell Cycle DNA Repair  map  / BER  map

References
PMID:19004803
CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest
PMID:12124778, PMID:19652693, PMID:15917306
Role in BER
PMID:23485469

GADD45A@Nucleus

References
ce_re8( Cell Cycle DNA Repair  map ):
GADD45 modulated and causes complex formation APE:PCNA. GADD is rgulated by p53:
PMID:17599061, PMID:23485469
ce_re254( Cell Cycle DNA Repair  map ):
GADD45 interacts with PCNA and activates NER-only Global(GG-NER):
PMID:19652693, PMID:10779360

Modifications:
In compartment: Nucleus
  1. GADD45A@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. GADD45A:​PCNA@Nucleus map
  2. CDK1:​CyclinB1*:​GADD45A@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. rGADD45*@Nucleus map → map GADD45A@Nucleus map
  2. GADD45A@Nucleus map + PCNA@Nucleus map → map GADD45A:​PCNA@Nucleus map
  3. CDK1:​CyclinB1*@Nucleus map + GADD45A@Nucleus map → map CDK1:​CyclinB1*:​GADD45A@Nucleus map
As Catalyser:
  1. gGG-NER_DNA_st2*@Nucleus map → map gTC-NER_GG-NER_DNA_st3*@Nucleus map
  2. G2 phase@Nucleus map → map M phase@Nucleus map
  3. gGG-NER_DNA_st1*@Nucleus map → map gGG-NER_DNA_st2*@Nucleus map
  4. Mg2+@Nucleus map + APE*|​Thr233_pho|​ubi@Nucleus map + PCNA@Nucleus map + WRN@Nucleus map → map APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@Nucleus map