Identifiers
APEX nuclease (multifunctional DNA repair enzyme) 1
HUGO:APEX1, ENTREZ:328, UNIPROT:P27695
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
HUGO:APEX2, ENTREZ:27301, UNIPROT:Q9UBZ4

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair   / BER 

References
Apyrimidinic endonucleases, APE
PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20056333, PMID:11585362
For Phosphorylation by CK2
PMID:20955519, PMID:9407949
Inhibitors for APE in combination with oxidative stress to block BER and cause cancer cell death
PMID:23110144, PMID:22455312
CDK5 and MDM2 activate APE for shift to BER activity
PMID:21727086, PMID:21922195

References
ce_re554:( Cell Cycle DNA Repair  ) PMID:21727086, PMID:21922195, PMID:20724832
ce_re2:( Cell Cycle DNA Repair  ) deoxyribose-phosphatase activity of PolB
ce_re8( Cell Cycle DNA Repair  ):
GADD45 modulated and causes complex formation APE:PCNA. GADD is rgulated by p53:
PMID:17599061, PMID:23485469
ce_re492( Cell Cycle DNA Repair  ):
PMID:20955519
PMID:9407949

References
ce_re492( Cell Cycle DNA Repair  ):
PMID:20955519
PMID:9407949

References
ce_re554:( Cell Cycle DNA Repair  ) PMID:21727086, PMID:21922195, PMID:20724832

1. APE*@Nucleus
2. APE*|​pho@Nucleus
3. APE*|​Thr233_pho|​ubi@Nucleus

1. APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@Nucleus

1. APE*|​Thr233_pho|​ubi@Nucleus → APE*|​pho@Nucleus
2. APE*@Nucleus → APE*|​Thr233_pho|​ubi@Nucleus
3. Mg2+@Nucleus + APE*|​Thr233_pho|​ubi@Nucleus + PCNA@Nucleus + WRN@Nucleus → APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@Nucleus

1. gBER_M-glyc_DNA_st2*@Nucleus → gBER_M-glyc_DNA_st3*@Nucleus
2. gBER_M-glyc_DNA_st3*@Nucleus → gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + 5'dRP@Nucleus
3. gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + dNTPs@Nucleus → gShP_BER_M-glyc_st5_B-glyc_DNA_st5*@Nucleus
4. gBER_B-glyc_DNA_st3*@Nucleus → gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + 3'ddR5P@Nucleus