Complex ATR:ATRIP map
Complex composition:

  1. ATR map
  2. ATRIP map

ATRIP:​ATR|​pho@Nucleus

Identifiers
NAME:ATR:ATRIP

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map

References
PMID:15743907
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580
ce_re260( Cell Cycle DNA Repair  map ):
DNA with O6-methylguanine adducts, MutSalpha and MutLalpha activate ATR/ATRIP and BER pathways performs the repair:
PMID:16713580, PMID:18543256
Damaged DNA triggers ATR/ATRIP complex activation
ce_re5( Cell Cycle DNA Repair  map ):
9-1-1 complex activates TDG glycosylase and activates BER:
PMID:17855402
ce_re33:( Cell Cycle DNA Repair  map ) PMID:15485915
ce_re120( Cell Cycle DNA Repair  map ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141
ce_re463( Cell Cycle DNA Repair  map ):
Arrests cell cycle in S-phase in response to stalled replication fork or ds breaks in DNA:
PMID:15459660, PMID:17384638, PMID:19793801

Modifications:
Participates in complexes:
In compartment: Nucleus
  1. ATRIP:​ATR|​pho@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. ATR|​pho|​active@Nucleus map + ATRIP@Nucleus map → map ATRIP:​ATR|​pho@Nucleus map
  2. TOPBP1@Nucleus map + ATRIP:​ATR|​pho@Nucleus map + CLSPN|​pho@Nucleus map + RAD17|​pho@Nucleus map → map ATRIP:​ATR|​pho:​CLSPN|​pho:​RAD17|​pho:​TOPBP1@Nucleus map
  3. ATRIP:​ATR|​pho@Nucleus map + CLSPN|​pho@Nucleus map + RPA1:​RPA2:​RPA3@Nucleus map → map ATRIP:​ATR|​pho:​CLSPN|​pho@Nucleus map
  4. HCLK2*@Nucleus map + CLSPN|​pho@Nucleus map + ATRIP:​ATR|​pho@Nucleus map + CHEK1|​pho|​active@Nucleus map → map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@Nucleus map
  5. TIM1*@Nucleus map + CLSPN|​pho@Nucleus map + PCNA|​K164_ubi@Nucleus map + ATRIP:​ATR|​pho@Nucleus map + CHEK1|​pho|​active@Nucleus map → map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@Nucleus map
As Catalyser:
  1. G2 phase@Nucleus map → map M phase@Nucleus map
  2. CHEK1@Nucleus map → map CHEK1|​pho|​active@Nucleus map
  3. CLSPN@Nucleus map → map CLSPN|​pho@Nucleus map
  4. gDeaminated_alkylated_mismatched_base*@Nucleus map → map gBER_M-glyc_DNA_st2*@Nucleus map + Base@Nucleus map