Protein TIM1* map

Identifiers
timeless homolog (Drosophila)
HUGO:TIMELESS, HGNC:11813, ENTREZ:8914, UNIPROT:Q9UNS1

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / S_PHASE_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / S_CC_PHASE  map

References
PMID:17102137, PMID:17116885, PMID:12875843, PMID:17296725, PMID:15798197
Role of TIM/TIPIN complex in DNA replication
PMID:17141802, PMID:12875843
For S-phase checkpoint
PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104

Modifications:
In compartment: Nucleus
  1. TIM1*@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. TIM1*:​TIPIN@Nucleus map
  2. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​TIM1*:​TIPIN@Nucleus map
  3. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. TIM1*@Nucleus map + CLSPN|​pho@Nucleus map + PCNA|​K164_ubi@Nucleus map + ATRIP:​ATR|​pho@Nucleus map + CHEK1|​pho|​active@Nucleus map → map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@Nucleus map
  2. TIPIN@Nucleus map + TIM1*@Nucleus map → map TIM1*:​TIPIN@Nucleus map
  3. ATRIP:​ATR|​pho:​CLSPN|​pho@Nucleus map + TIPIN@Nucleus map + TIM1*@Nucleus map + CHEK1|​pho|​active@Nucleus map → map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​TIM1*:​TIPIN@Nucleus map
As Catalyser:
  1. S phase@Nucleus map → map G2 phase@Nucleus map
  2. gDamaged_DNA*@Nucleus map → map gRepaired_DNA*@Nucleus map
  3. ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@Nucleus map + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@Nucleus map + CDT1@Nucleus map + CDC6@Nucleus map + CDC45@Nucleus map + POLA*@Nucleus map + PRIM*@Nucleus map + RPA1@Nucleus map + RPA2@Nucleus map + RPA3@Nucleus map → map CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*@Nucleus map
  4. No DNA replicarion@Nucleus map → map DNA replicarion@Nucleus map