Protein AXIN* map

Identifiers
axin 1
HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1
axin 2
HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:17143292

AXIN*@Nucleus

References
su_wnc1_s_wnc4_re8:( Survival  map ) PMID:15526030

AXIN*@Cytoplasm

References
s_wnc4_re45:( Survival  map ) PMID:17588722

AXIN*@Cytoplasm

References
s_wca1_re39:( Survival  map ) PMID:21606194
s_wca2_re7( Survival  map ):
The protein is Parsylated but cannot be depicted as such in the program. Glutamic acids are parsylated.
PMID:17825467
Both TNKS are required for parsylation of AXIN1/2
PMID:19759537
PMID:21799911
s_wnc4_re32:( Survival  map ) PMID:16868183

AXIN*@Cytoplasm

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

AXIN*|​E_unk|​E_unk@Cytoplasm

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
?=parsylated
s_wca2_re7( Survival  map ):
The protein is Parsylated but cannot be depicted as such in the program. Glutamic acids are parsylated.
PMID:17825467
Both TNKS are required for parsylation of AXIN1/2
PMID:19759537
PMID:21799911
s_wca2_re8( Survival  map ):
PMID:21478859
su_wca1_s_wca2_re8( Survival  map ):

AXIN*|​E_unk|​E_unk|​K63_ubi|​K48_ubi|​K11_ubi@Cytoplasm

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
s_wca2_re8( Survival  map ):
PMID:19759537
PMID:21799911
PMID:21478859

AXIN*@Nucleus

References
s_wca3_re18( Survival  map ):
The exact mechanism is depicted in the cytoplasmic fraction. Although the articles do not mention where exactly the reactions occurs TNKS are found in the cytoplasm and in the nucleus.
PMID:17825467
PMID:19759537
PMID:21799911
s_wnc4_re8:( Survival  map ) PMID:15526030

AXIN*|​ubi|​ubi@Nucleus

References
s_wca3_re18( Survival  map ):
The exact mechanism is depicted in the cytoplasmic fraction. Although the articles do not mention where exactly the reactions occurs TNKS are found in the cytoplasm and in the nucleus.
PMID:17825467
PMID:19759537
PMID:21799911

Modifications:
In compartment: Cytoplasm
  1. AXIN*@Cytoplasm map
  2. AXIN*@Cytoplasm map
  3. AXIN*@Cytoplasm map
  4. AXIN*|​E_unk|​E_unk@Cytoplasm map
  5. AXIN*|​E_unk|​E_unk|​K63_ubi|​K48_ubi|​K11_ubi@Cytoplasm map
In compartment: Nucleus
  1. AXIN*@Nucleus map
  2. AXIN*@Nucleus map
  3. AXIN*|​ubi|​ubi@Nucleus map
Participates in complexes:
In compartment: Cytoplasm
  1. AXIN*:​G_alpha__sub_12_endsub_*@Cytoplasm map
  2. APC|​S1505_pho|​S1501_ubi|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_ubi:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho@Cytoplasm map
  3. AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map
  4. AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map
  5. APC|​K63_ubi:​AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map
  6. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map
  7. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map
  8. APC:​AXIN*|​S80_emp|​S82_emp|​S222_emp|​S473_emp:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map
  9. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map
  10. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_emp|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map
  11. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map
  12. APC:​AXIN*:​Actin cytoskeletal*:​DVL*:​HSC70*:​HSP70*:​HTID1_50_48_kDa_isoform*@Cytoplasm map
  13. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map
  14. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*@Cytoplasm map
  15. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho@Cytoplasm map
  16. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho@Cytoplasm map
  17. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho@Cytoplasm map
  18. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  19. AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  20. AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  21. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  22. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  23. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  24. APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm map
  25. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  26. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm map
In compartment: Endosome
  1. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map
  2. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  3. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  4. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  5. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  6. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  7. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  8. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
In compartment: Nucleus
  1. AXIN*:​HIPK2@Nucleus map
  2. AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map + _beta_-Catenin*@Cytoplasm map → map AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*@Cytoplasm map
  2. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map → map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  3. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map → map AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_emp|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map
  4. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_emp|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map → map AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map
  5. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map + PPP1C*:​PPP1R*@Cytoplasm map → map AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map
  6. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map → map APC:​AXIN*|​S80_emp|​S82_emp|​S222_emp|​S473_emp:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map
  7. APC:​AXIN*|​S80_emp|​S82_emp|​S222_emp|​S473_emp:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map → map GSK3*@Cytoplasm map + AMER1*:​APC:​AXIN*:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map + PPP1C*:​PPP1R*@Cytoplasm map
  8. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*@Cytoplasm map → map AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho@Cytoplasm map
  9. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map + PP2A_C*:​PR55_alpha_*:​PR65_A*@Cytoplasm map → map AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  10. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map → map APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm map
  11. APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm map → map PP2A_C*:​PR55_alpha_*:​PR65_A*@Cytoplasm map + _beta_-Catenin*@Cytoplasm map + AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map
  12. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho@Cytoplasm map → map AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho@Cytoplasm map
  13. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  14. AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map + APC@Cytoplasm map + AMER1*@Cytoplasm map → map AMER1*:​APC:​AXIN*:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map
  15. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  16. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  17. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  18. CK1_alpha_*@Cytoplasm map + AXIN*@Cytoplasm map + GSK3*@Cytoplasm map → map AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map
  19. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho@Cytoplasm map → map AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho@Cytoplasm map
  20. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  21. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  22. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map → map CK1_epsilon_*:​p120*|​S268_pho|​S269_pho@Endosome map + E-Cadherin*|​pho@Endosome map + AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  23. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map → map AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map
  24. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map → map AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map
  25. GTP:​G_alpha_o*@Cytoplasm map + AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map + _beta_-Arrestin2*@Cytoplasm map → map AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map
  26. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map + CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm map + CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​PKD*:​USP15@Cytoplasm map → map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm map
  27. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm map → map CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​NEDD8:​PKD*:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_TRCP*@Cytoplasm map + APC|​S1505_pho|​S1501_ubi|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_ubi:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho@Cytoplasm map + _beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map
  28. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho@Cytoplasm map → map AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  29. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map → map AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  30. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map → map Recycling @Cytoplasm map
  31. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map → map Degradation@Cytoplasm map
  32. AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map → map AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  33. AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map → map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  34. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map → map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  35. APC|​K63_ubi@Cytoplasm map + AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map → map APC|​K63_ubi:​AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map
  36. APC|​K63_ubi:​AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map → map WNT canonical pathway@Cytoplasm map
  37. AXIN*@Cytoplasm map → map AXIN*|​E_unk|​E_unk@Cytoplasm map
  38. AXIN*|​E_unk|​E_unk@Cytoplasm map → map AXIN*|​E_unk|​E_unk|​K63_ubi|​K48_ubi|​K11_ubi@Cytoplasm map
  39. AXIN*|​E_unk|​E_unk|​K63_ubi|​K48_ubi|​K11_ubi@Cytoplasm map → map degraded
  40. AXIN*|​ubi|​ubi@Nucleus map → map AXIN*@Nucleus map
  41. AXIN*@Nucleus map → map AXIN*|​ubi|​ubi@Nucleus map
  42. AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map → map Apoptosis@Nucleus map
  43. AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map → map p53-target genes@Nucleus map
  44. G_alpha__sub_12_endsub_*@Cytoplasm map + AXIN*@Cytoplasm map → map AXIN*:​G_alpha__sub_12_endsub_*@Cytoplasm map
  45. APC@Cytoplasm map + HTID1_50_48_kDa_isoform*@Cytoplasm map + HSP70*@Cytoplasm map + DVL*@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map + AXIN*@Cytoplasm map + HSC70*@Cytoplasm map → map APC:​AXIN*:​Actin cytoskeletal*:​DVL*:​HSC70*:​HSP70*:​HTID1_50_48_kDa_isoform*@Cytoplasm map
  46. AXIN*@Nucleus map + p53*@Nucleus map + HIPK2@Nucleus map → map AXIN*:​HIPK2@Nucleus map
  47. AXIN*:​HIPK2@Nucleus map → map AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map
As Catalyser:
  1. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  2. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map