Identifiers
HUGO:JUN
Jun proto-oncogene, AP-1 transcription factor subunit
HUGO:JUN hgnc_id:HGNC:6204 HGNC:6204 ENTREZ:3725 UNIPROT:P05412
jun proto-oncogene
"jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)"
HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412
Jun
HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN
Maps_Modules
HMC:ENABLING_REPLICATION_AND_IMMORTALITY
Telomere Maintenance / TELOMERASE
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / ER_STRESS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / HEDGEHOG
Survival / WNT_CANONICAL
Survival / WNT_NON_CANONICAL
References
PMID:26587781
AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers.
PMID:11274345
PMID:17439715
PMID:8545107
Jun proto-oncogene
References
mo_re298:( motility ) PMID:29556339
References
mo_re298:( motility ) PMID:29556339
mo_re51:( motility ) PMID:23589069 PMID:22131018 PMID:29556339
References
s_wca3_re169( Survival ):
Upon WNT3a stimulation formation complex DVL with c-jun
PMID:18347071
→ JUN|pho|active@Nucleus
→ JUN|pho@Nucleus
+ CHOP*@Nucleus + GCN5*@Nucleus → CHOP*:GCN5*:JUN|pho@Nucleus
→ AP-1*@Cytosol
+ ATF2|pho@Nucleus → su_mpk1_mpk1_s1050
→ su_mpk1_mpk1_s1051
+ FOS|pho@Nucleus → su_mpk1_mpk1_s1052
→ JUN|pho@Nucleus
→ JUN|S63_pho|S73_pho|active@Nucleus
→ JUN|S63_pho|S73_pho|active@Nucleus
+ gpromoter_region@Nucleus → JUN|S63_pho|S73_pho:promoter_region@Nucleus
+ gpromoter_region@Nucleus + JUN|S63_pho|S73_pho|active@Nucleus → GLI1|pho|pho:JUN|S63_pho|S73_pho:promoter_region@Nucleus
+ JUN|S63_pho|S73_pho|active@Nucleus → JUN|S63_pho|S73_pho:promoter_region@Nucleus
+ BCL9:DVL*:JUN|pho|pho:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*|K345_ace|ace@Nucleus → APC|T1487_pho:BCL9:CTBP*|hm2:DVL*:HDAC1_2*:JUN|pho|pho:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*|K345_ace|ace@Nucleus
→ APC|T1487_pho:_beta_-Catenin*|K345_ace|ace@Nucleus + su_wca1_s_wca3_s405 + CTBP*:HDAC1_2*:LEF_TCF*:WRE*@Nucleus + DVL*:JUN|pho|pho@Nucleus
+ BCL9:CBP*|S92_pho:DVL*:JUN|pho|pho:PYGO*:_beta_-Catenin*|ace|ace@Nucleus → BCL9:CBP*|S92_pho:DVL*:JUN|pho|pho:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*|K345_emp|ace|ace@Nucleus + HDAC1_2*:TLE*|ubi@Nucleus
+ DVL*@Nucleus → DVL*:JUN|pho|pho@Nucleus
+ DVL*:JUN|pho|pho@Nucleus → BCL9:DVL*:JUN|pho|pho:PYGO*:_beta_-Catenin*|K345_ace|ace@Nucleus
+ BCL9:CBP*|S92_pho:PYGO*:_beta_-Catenin*|ace|ace@Nucleus → BCL9:CBP*|S92_pho:DVL*:JUN|pho|pho:PYGO*:_beta_-Catenin*|ace|ace@Nucleus
+ BCL9:DVL*:JUN|pho|pho:PYGO*:_beta_-Catenin*|K345_ace|ace@Nucleus → BCL9:DVL*:JUN|pho|pho:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*|K345_ace|ace@Nucleus + HDAC1_2*:TLE*|ubi@Nucleus
→ JUN@Nucleus
→ Transcription@Nucleus
→ Growth arrest@Nucleus
→ DNA repair@Nucleus
→ Cell death@Nucleus
→ Proliferation@Nucleus
→ JUN@Nucleus
+ gAP-1_ARRE binding sites*@Nucleus + JUN@Nucleus + FOS@Nucleus → AP-1_ARRE binding sites*:NFAT*@Nucleus + CNA*:CNB*@Nucleus + ERK2*@Nucleus + MEK1*@Nucleus
+ JUN@Nucleus + FOS@Nucleus + NFAT*@Nucleus → AP-1_ARRE binding sites*:NFAT*@Nucleus
→ rMMP7@Nucleus
→ rTNFRSF10B@Nucleus
→ rDR4*@Nucleus
→ ERK*@Cytoplasm
→ rFOXA2@Nucleus
→ rJAG2@Nucleus
→ rCyclinD*@Nucleus
→ rJUN@Nucleus
→ rIL1R2@Nucleus
→ rS100A9@Nucleus
→ rARC@Nucleus
→ rULK1@Nucleus
→ rRNA@Nucleus
→ rTCF4@Nucleus
→ rRAD6B*@Nucleus
→ rBCL9@Nucleus
→ arMIR372@Nucleus
→ arMIR373@Nucleus
→ rIRS2@Nucleus
→ rCRIPTO-1*@Nucleus
→ rMYC@Nucleus
→ rRNA@Nucleus
→ rTERT@Nucleus