Identifiers
heat shock 70kDa protein 1A
HUGO:HSPA1A
heat shock 70kDa protein 1B
HUGO:HSP1B
heat shock 70kDa protein 1-like
HUGO:HSPA1L
HUGO:HSPA1A HGNC:5232 ENTREZ:3303 UNIPROT:P08107
HUGO:HSPA1B HGNC:5233 ENTREZ:3304 UNIPROT:P08107
HUGO:HSPA1L HGNC:5234 ENTREZ:3305 UNIPROT:P34931
"heat shock 70kD protein 1A", HSPA1
HUGO:HSPA1A HGNC:5232 ENTREZ:3303 UNIPROT:P08107 GENECARDS:HSPA1A REACTOME:56682 KEGG:3303 ATLASONC:GC_HSPA1A WIKI:HSPA1A HUGO:HSPA1B HGNC:5233 ENTREZ:3304 UNIPROT:P08107 GENECARDS:HSPA1B REACTOME:56682 KEGG:3304 ATLASONC:GC_HSPA1B WIKI:HSPA1B

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / RCD_GENES 
 Regulated Cell Death   / ER_STRESS 
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity   / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_NON_CANONICAL 

References
PMID:20959453
PMID:23430059
CASCADE:TLR2_4
PMID:25103413
Hypoxia downregulates HSP70 level in membrane.
PMID:20093776
Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells via TLR2/MyD88 dependent IL6 expression.

References
te_re100:( Telomere Maintenance  ) PMID:22032831 PMID:20959453

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / RCD_GENES 

References
s_wnc4_re45:( Survival  ) PMID:17588722

1. HSP70*@Cytoplasm

1. HSP70*@Cytosol

1. HSP70*@Endopasmic Reticulum

1. HSP70*@TUMOR_CELL_AS_INDUCTOR

1. HSP70*@default

1. APC:​AXIN*:​Actin cytoskeletal*:​DVL*:​HSC70*:​HSP70*:​HTID1_50_48_kDa_isoform*@Cytoplasm

1. HSP70*:​HSP90*|​hm2:​STUB1:​TERT@Cytosol
2. HSP70*:​HSP90*|​hm2:​STUB1:​TERT|​ubi@Cytosol
3. HSP70*:​HSP90*|​hm2:​PTGES3:​STUB1:​TERT@Cytosol

1. HSP70*:​IRE1-alpha*@Endopasmic Reticulum

1. HSP70*@TUMOR_CELL_AS_INDUCTOR → HSP70*@default
2. rHSP70*@Nucleus → HSP70*@Cytosol
3. IRE1-alpha*@Endopasmic Reticulum + HSP70*@Endopasmic Reticulum → HSP70*:​IRE1-alpha*@Endopasmic Reticulum
4. APAF1@Cytosol + HSP70*@Cytosol → rc_s1590
5. HSP70*@Cytosol + cleaved~AIFM1*@Cytosol → rc_s3328
6. APC@Cytoplasm + HTID1_50_48_kDa_isoform*@Cytoplasm + HSP70*@Cytoplasm + DVL*@Cytoplasm + Actin cytoskeletal*@Cytoplasm + AXIN*@Cytoplasm + HSC70*@Cytoplasm → APC:​AXIN*:​Actin cytoskeletal*:​DVL*:​HSC70*:​HSP70*:​HTID1_50_48_kDa_isoform*@Cytoplasm
7. HSP90*|​hm2:​PTGES3:​TERT@Cytosol + STUB1@Cytosol + HSP70*@Cytosol → HSP70*:​HSP90*|​hm2:​PTGES3:​STUB1:​TERT@Cytosol
8. HSP70*:​HSP90*|​hm2:​PTGES3:​STUB1:​TERT@Cytosol → HSP70*:​HSP90*|​hm2:​STUB1:​TERT@Cytosol + PTGES3@Cytosol
9. HSP70*:​HSP90*|​hm2:​STUB1:​TERT@Cytosol → HSP70*:​HSP90*|​hm2:​STUB1:​TERT|​ubi@Cytosol
10. HSP70*:​HSP90*|​hm2:​STUB1:​TERT|​ubi@Cytosol → degraded

1. TLR2/4*@INNATE_IMMUNE_CELL_Membrane + LY96@INNATE_IMMUNE_CELL_Membrane + TIRAP@INNATE_IMMUNE_CELL_Membrane + MYD88@INNATE_IMMUNE_CELL_Membrane + CD14@INNATE_IMMUNE_CELL_Membrane → CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane
2. Lysosome membrane~integrity@Lysosome + hydroxyl@Cytosol → LMP@Lysosome
3. Cytochrome_C*|​ferroheme@Cytosol + (d)ATP@Cytosol + APAF1@Cytosol → (d)ATP:​APAF1:​Cytochrome_C*|​ferroheme@Cytosol