Protein cleaved~Caspase3* map

Identifiers
caspase 3, apoptosis-related cysteine peptidase
HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map
 Regulated Cell Death  map  / ER_STRESS  map

References
PMID:19931333

cleaved~Caspase3*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

cleaved~Caspase3*@Mitochondrial intermembrane space

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re683:( Regulated Cell Death  map ) PMID:15186778

cleaved~Caspase3*@Nucleus

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re420( Regulated Cell Death  map ):
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:19219071
rc_re615( Regulated Cell Death  map ):
PMID:12217801
in Jurkat, Fas induces HRK expression and DREAM:HRK-promoter dissociation (EMSA), which is blocked by z-VAD-fmk
in vitro, caspase 3 could cleave DREAM
rc_re684( Regulated Cell Death  map ):
PMID:9092486

Modifications:
In compartment: Cytosol
  1. cleaved~Caspase3*@Cytosol map
In compartment: Mitochondrial intermembrane space
  1. cleaved~Caspase3*@Mitochondrial intermembrane space map
In compartment: Nucleus
  1. cleaved~Caspase3*@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Caspase3*@Cytosol map → map cleaved~Caspase3*@Cytosol map
    2. Caspase3*@Cytosol map → map cleaved~Caspase3*@Cytosol map
    3. cleaved~Caspase3*@Cytosol map → map Apoptotic death@Cytosol map
    4. Caspase3*@Cytosol map → map cleaved~Caspase3*@Cytosol map
    5. cleaved~Caspase3*@Cytosol map → map Apoptosis@Cytosol map
    6. cleaved~Caspase3*@Cytosol map → map Caspase3_cl_uncl*@Cytosol map
    7. cleaved~Caspase3*@Cytosol map → map cleaved~Caspase3*@Nucleus map
    8. cleaved~Caspase3*@Cytosol map → map active~Caspases*@Cytosol map
    9. Caspase3*@Cytosol map → map cleaved~Caspase3*@Cytosol map
    As Catalyser:
    1. BCL2|​unk@Mitochondrial inner membrane map → map cleaved~BCL2*@Mitochondrial inner membrane map
    2. AKT1@Cytosol map → map cleaved~AKT1*@Cytosol map
    3. ATM|​unk|​K3016_unk@Nucleus map → map cleaved~ATM*@Site of DNA damage map
    4. BIRC2@Cytosol map → map cleaved~BIRC2*@Cytosol map
    5. GCLC@Cytosol map → map cleaved~GCLC*@Cytosol map
    6. 14-3-3*@Cytosol map → map cleaved~14-3-3*@Cytosol map
    7. MCL1|​S159_unk@Mitochondrial inner membrane map → map cleaved~MCL1*@Mitochondrial inner membrane map
    8. FUBP1@Nucleus map → map cleaved_FUBP1*@Nucleus map
    9. BID@Cytosol map → map cleaved_BID*@Cytosol map
    10. KCNIP3@Nucleus map → map cleaved~KCNIP3*@Nucleus map
    11. IKK_beta_*@Cytosol map → map cleaved~IKBKB*@Cytosol map
    12. FMN:​MT-ND1:​MT-ND2:​MT-ND3:​MT-ND4:​MT-ND4L:​MT-ND5:​MT-ND6:​NDUFA1:​NDUFA10:​NDUFA11:​NDUFA12:​NDUFA13:​NDUFA2:​NDUFA3:​NDUFA4:​NDUFA5:​NDUFA6:​NDUFA7:​NDUFA8:​NDUFA9:​NDUFAB1:​NDUFB1:​NDUFB10:​NDUFB11:​NDUFB2:​NDUFB3:​NDUFB4:​NDUFB5:​NDUFB6:​NDUFB7:​NDUFB8:​NDUFB9:​NDUFC1:​NDUFC2:​NDUFS1|​[2Fe-2S],[4Fe-4S],[4Fe-4S]:​NDUFS2:​NDUFS3:​NDUFS4:​NDUFS5:​NDUFS6:​NDUFS7|​[4Fe-4S]:​NDUFS8|​[4Fe-4S],[4Fe-4S]:​NDUFV1|​[4Fe-4S]:​NDUFV2|​[2Fe-2S]:​NDUFV3@Mitochondrial inner membrane map → map cleaved~NDUFS1*@Mitochondrial intermembrane space map
    13. RB1@Nucleus map → map cleaved_RB1*@Nucleus map
    14. DFFA:​DFFB@Cytosol map → map DFFB@Cytosol map + cleaved~DFFA*@Cytosol map
    15. Caspase6*@Cytosol map → map cleaved~Caspase6*@Cytosol map