Protein cleaved~MCL1* map

Identifiers
myeloid cell leukemia sequence 1 (BCL2-related)
HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
whether CASP3- and GMZB-mediated cleavage products of MCL1 retain some anti-apoptotic activity or gain pro-apoptotic activity is a matter of debated
PMID:15713684

cleaved~MCL1*@Mitochondrial inner membrane

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re42( Regulated Cell Death  map ):
influenceDelete: reactants to re
we consider only that CASP3 or GZMB activity can influence Bax recruitment to membrane, not the fact that MCL1 increases it
hierarchical:post-MOMP
reactionType:proteases.cleavage
PMID:15713684
in different human cancer cell lines by Granzyme B
PMID:15637055
in Jurkat leukemia T cells, by CASP3 upon TRAIL-induced apoptosis
rc_re29( Regulated Cell Death  map ):
PMID:19968986
cleaved MCL1
PMID:14730312
ASC/PYCARD
PMID:19062087
in vitro in reconstituted liposomes, tBid is sufficient to induce Bax insertion into membrane and oligomerization

Modifications:
In compartment: Mitochondrial inner membrane
  1. cleaved~MCL1*@Mitochondrial inner membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MCL1|​S159_unk@Mitochondrial inner membrane map → map cleaved~MCL1*@Mitochondrial inner membrane map
    As Catalyser:
    1. BAX@Cytosol map → map BAX|​S163_unk|​T167_unk@Mitochondrial inner membrane map