Complex DFFA:DFFB map
Complex composition:

  1. DFFA map
  2. DFFB map

DFFA:​DFFB@Cytosol

Identifiers
NAME:DFFA:DFFB

References
rc_re687( Regulated Cell Death  map ):
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:9108473
purification of DFFA:DFFB activity from Hela cells cytosol
in vitro, CASP3 mediated of DFFA necessary for nucleosomal DNA fragmentation
in U937 monocyte cells, in Hela cells, in SV589 human fibroblasts, upon staurosporin, DFFA cleaved into the same fragments as in vitro
PMID:9422506
purification and cloning of ICAD:CAD (mouse homologs) from mouse T-cell lymphoma cytosol
CASP3-mediated cleavage of ICAD releases CAD, leading to activation of its enzymatic activity and its nuclear localization

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. DFFA:​DFFB@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. DFFA:​DFFB@Cytosol map → map DFFB@Cytosol map + cleaved~DFFA*@Cytosol map
  2. DFFA@Cytosol map + DFFB@Cytosol map → map DFFA:​DFFB@Cytosol map
As Catalyser: