Protein Caspase3* map

Identifiers
caspase 3, apoptosis-related cysteine peptidase
"caspase 3, apoptosis-related cysteine protease"
HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574
HUGO:CASP3
HGNC:1504 ENTREZ:836 UNIPROT:P42574
HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 GENECARDS:CASP3 REACTOME:57022 KEGG:836 ATLASONC:GC_CASP3 WIKI:CASP3

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / SENESCENCE  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / ER_STRESS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:11989976
PMID:17959595
Caspase1,3 promote proteosomal degradation of ARHGDIB
PMID:19931333
PMID:26618107
CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented.
PMID:17613518
PMID:9765224

Caspase3*|​-SNO@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re1024:( Regulated Cell Death  map ) PMID:10213689

Caspase3*@Cytoplasm

References
su_mpk1_mpk1_re34( Survival  map ):
Activated caspase-9 cleaves and activates caspase-3 leading to apoptosis.
PMID:9390557
su_akt1_s_akt1_re187:( Survival  map ) PMID:9765224
su_akt1_s_akt1_re189:( Survival  map ) PMID:19440234

Caspase3*@Cytoplasm

References
s_akt1_re187:( Survival  map ) PMID:9765224

Modifications:
In compartment: Cytoplasm
  1. Caspase3*@Cytoplasm map
  2. Caspase3*@Cytoplasm map
In compartment: Cytosol
  1. Caspase3*@Cytosol map
  2. Caspase3*|​-SNO@Cytosol map
Participates in complexes:
In compartment: Cytoplasm
  1. Caspase3*:​p21CIP1*|​T145_pho@Cytoplasm map
In compartment: Cytosol
  1. Caspase3*:​HSPB1@Cytosol map
  2. Caspase3*:​XIAP|​S87_unk@Cytosol map
  3. Caspase3*:​DCC:​NTN1@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. Caspase*@Cytosol map → map Caspase3*@Cytosol map
  2. Caspase3*@Cytosol map + NO@Cytosol map → map Caspase3*|​-SNO@Cytosol map
  3. XIAP|​S87_unk@Cytosol map + Caspase3*@Cytosol map → map Caspase3*:​XIAP|​S87_unk@Cytosol map
  4. Caspase3*@Cytosol map → map cleaved~Caspase3*@Cytosol map
  5. Caspase3*:​DCC:​NTN1@Cytosol map → map NTN1@Extracellular space map + Cleaved DCC*@Cytosol map
  6. Caspase3*@Cytosol map → map cleaved~Caspase3*@Cytosol map
  7. Caspase3*@Cytosol map → map cleaved~Caspase3*@Cytosol map
  8. Caspase3*@Cytosol map + HSPB1@Cytosol map → map Caspase3*:​HSPB1@Cytosol map
  9. Caspase3*@Cytosol map → map Caspase3_cl_uncl*@Cytosol map
  10. rCaspase3*@Nucleus map → map Caspase3*@Cytosol map
  11. Caspase3*@Cytosol map → map cleaved~Caspase3*@Cytosol map
  12. Caspase3*@Cytoplasm map → map Caspase3*@Cytoplasm map
  13. p21CIP1*|​T145_pho|​T146_pho@Cytoplasm map + Caspase3*@Cytoplasm map → map Caspase3*:​p21CIP1*|​T145_pho@Cytoplasm map
  14. Caspase3*@Cytoplasm map → map Apoptosis@Mitochondria map
  15. Caspase3*@Cytoplasm map → map Caspase3_sub_TRUNC_endsub_*@Cytoplasm map
As Catalyser: