Identifiers
myeloid cell leukemia sequence 1 (BCL2-related)
HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / ER_STRESS
References
PMID:23850759
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / MOMP_REGULATION
References
rc_re45:( Regulated Cell Death ) reactionType:is.a
rc_re42( Regulated Cell Death ):
influenceDelete: reactants to re
we consider only that CASP3 or GZMB activity can influence Bax recruitment to membrane, not the fact that MCL1 increases it
hierarchical:post-MOMP
reactionType:proteases.cleavage
PMID:15713684
in different human cancer cell lines by Granzyme B
PMID:15637055
in Jurkat leukemia T cells, by CASP3 upon TRAIL-induced apoptosis
rc_re586( Regulated Cell Death ):
PMID:15486085
MCL1-BIM interaction in mitochondrial fraction independent of BIM S65 phosphorylation status
PMID:15724238
in human tonsil B cells, constitutive interaction
rc_re605( Regulated Cell Death ):
PMID:11546872
in HEK293T, coIP
Y2H
rc_re612( Regulated Cell Death ):
PMID:15031724
Y2H with human cDNA
rc_re1417( Regulated Cell Death ):
PMID:20501829
in DU-145 upon ER stress induced by IL24 ectopic expression
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / MOMP_REGULATION
References
rc_re41( Regulated Cell Death ):
PMID:15989957
in Hela MCL1 ubiquitination mainly on lysines 136, 194, and 197
purification of MCL1 E3 ubiquitin ligase from the cytosol of Hela cells
in vitro reconstitution of the system
HUWE1 KD
PMID:16543145
suggest that HUWE1 preferentially target S159 phosphorylated MCL1 for polyubiquitination
PMID:16213503
HUWE1 is a BH3 domain protein - competition HUWE1 / Bim for binding to MCL1
rc_re95( Regulated Cell Death ):
PMID:20023629
in Hela and 293T, ectopically expressed USP9X binds and deubiquitinylates MCL1.
in human follicular lymphomas, USP9X overexpression correlates with MCL1 expression.
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / MOMP_REGULATION
References
rc_re40( Regulated Cell Death ):
logical:re40_s128_re45=FALSE
PMID:16543145
in different IL-3 dependent mouse pro-B cell lines upon IL-3 withdrawal
in Hela and 293T
S159 phosphorylation site correspond to human MCL1
GSK3A and GSK3B KD in NIH3T3
rc_re95( Regulated Cell Death ):
PMID:20023629
in Hela and 293T, ectopically expressed USP9X binds and deubiquitinylates MCL1.
in human follicular lymphomas, USP9X overexpression correlates with MCL1 expression.
rc_re41( Regulated Cell Death ):
PMID:15989957
in Hela MCL1 ubiquitination mainly on lysines 136, 194, and 197
purification of MCL1 E3 ubiquitin ligase from the cytosol of Hela cells
in vitro reconstitution of the system
HUWE1 KD
suggest that HUWE1 preferentially target S159 phosphorylated MCL1 for polyubiquitination
PMID:16213503
HUWE1 is a BH3 domain protein - competition HUWE1 / Bim for binding to MCL1
rc_re45:( Regulated Cell Death ) reactionType:is.a
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / MOMP_REGULATION
References
rc_re44( Regulated Cell Death ):
PMID:17404574
in human immortalized non malignant H69 cholangiocyte and malignant KMCH cholangiocarcinoma cell lines, MIR29B1 targets MCL1
PMID:19155302
MCL1 is a target of MIR101
PMID:19676043
in DBTRG-05MG human glioblastoma cell line, MCL1 targeted by MIR153
PMID:19654003
in H2009 human lung adenocarcinoma cells, MCL1 is a target of MIR133B
PMID:19966861
in Jurkat, HeLa, U937, glycolysis inhibition by 2deoxy glucose causes a specific block in transltion of MCL1, through a AMPK - TOR pathway
rc_re40( Regulated Cell Death ):
logical:re40_s128_re45=FALSE
PMID:16543145
in different IL-3 dependent mouse pro-B cell lines upon IL-3 withdrawal
in Hela and 293T
S159 phosphorylation site correspond to human MCL1
GSK3A and GSK3B KD in NIH3T3
rc_re46:( Regulated Cell Death ) reactionType:is.a
+ BAK1@Mitochondrial inner membrane → BAK1:MCL1|S159_unk@Mitochondrial inner membrane
→ Reorganization of ER membranes@Endopasmic Reticulum
→ MCL1|S159_pho@Mitochondrial inner membrane
→ MCL1|S159_pho|ubi@Mitochondrial inner membrane
→ cleaved~MCL1*@Mitochondrial inner membrane
→ MCL1@Mitochondrial inner membrane
→ MCL1|S159_unk@Mitochondrial inner membrane
→ MCL1|S159_unk@Mitochondrial inner membrane
→ degraded
+ MCL1|S159_unk@Mitochondrial inner membrane → BCL2L11:MCL1@Mitochondrial inner membrane
+ MCL1|S159_unk@Mitochondrial inner membrane → MCL1|S159_unk:cleaved_BID*|myr@Mitochondrial inner membrane
+ MCL1|S159_unk@Mitochondrial inner membrane → BBC3:MCL1|S159_unk@Mitochondrial inner membrane
+ MCL1|S159_unk@Mitochondrial inner membrane → MCL1|S159_unk:PMAIP1@Mitochondrial inner membrane
+ MCL1|S159_unk@Mitochondrial inner membrane → BMF|unk:MCL1|S159_unk@Mitochondrial inner membrane
+ MCL1|S159_unk@Mitochondrial inner membrane → HRK:MCL1|S159_unk@Mitochondrial inner membrane
→ MCL1|S159_pho@Mitochondrial inner membrane