Identifiers
BH3 interacting domain death agonist
HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957
HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 GENECARDS:BID REACTOME:50826 KEGG:637 ATLASONC:GC_BID WIKI:BID

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / ER_STRESS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_NON_CANONICAL 

References
PMID:23430059

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 

References
rc_re509( Regulated Cell Death  ):
PMID:11583622
BID phosphorylated in Hela, in L929 (murine fibrosarcoma cell line), in other cell lines
mass spectrometry analysis of BID phosphorylated in vitro by Jurkat or Hela extracts
mutagenesis experiments identifies S61 and S64 as the main phosphorylation site
purification of kinase activity in 3 different chromatography fractions
CSNK inhibits Fas-induced apoptosis in Hela D98/AH2 (Fas sensitive Hela)
PMID:12598529
by CSNK2 at T59
PMID:20356928
rc_re511:( Regulated Cell Death  ) reactionType:is.a
rc_re513( Regulated Cell Death  ):
in vitro, phosphorylation of BID has no effect on Granzyme B mediated cleavage

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 

References
rc_re510:( Regulated Cell Death  ) reactionType:is.a
rc_re514( Regulated Cell Death  ):
PMID:11940658
in vitro cleavage of BID by m-calpain
in human metastatic melanoma cell line, 224, in CASP3 deficient MCF-7 breast carcinoma cells, cleavage of BID by calpains and apoptosis in response to cisplatin
use of calpain inhibitors
involvment of mu-calpain cannot be ruled out
PMID:11404357
in rabbit heart mounted onto a Langendorff's perfusion apparatus, upon ischemia/reperfusion, cleavage of BID by calpains
in vitro cleavage of BID by recombinant mu-calpain
PMID:17264306
in human neutrophils, upon bacteria-induced lysosomal permeabilization, BID cleavage and apoptosis are reversed by cathepsin but not caspase inhibition
PMID:18469004
in different human cell lines (HeLa, MCF-7, SH-SY5Y, HaCaT, CaCo-2,HepG2), upon LeuLeuOMe-induced lysosomal membrane permeabilisation, cleavage of Bid and apoptosis, rescued by E-64d cathepsin inhibitor
rc_re517( Regulated Cell Death  ):
PMID:14687661
in NIH3T3 mouse embryonic fibroblasts over-expression of human HSP90B1 protects from TNF+CHX-induced apoptosis
co-IP experiments in same cells (not very convincing)

References
s_wnc2_re12:( Survival  ) PMID:21738214, PMID:20709625

1. BID@Cytoplasm

1. BID@Cytosol
2. BID|​pho@Cytosol
3. BID|​unk@Cytosol
4. BID|​pho|​active@Cytosol

1. BID|​unk:​HSP90B1@Cytosol

1. BID@Cytosol → cleaved_BID*@Cytosol
2. BID@Cytosol → BID|​pho|​active@Cytosol
3. BID|​pho|​active@Cytosol → Apoptosis@Cytosol
4. BID@Cytosol → cleaved_BID*@Cytosol
5. BID@Cytosol → BID|​pho@Cytosol
6. BID@Cytosol → BID|​unk@Cytosol
7. BID|​pho@Cytosol → BID|​unk@Cytosol
8. rBID@Nucleus → BID@Cytosol
9. BID|​pho@Cytosol → cleaved_BID*@Cytosol
10. BID|​unk@Cytosol → cleaved_BID*@Cytosol
11. BID|​unk@Cytosol + HSP90B1@Cytosol → BID|​unk:​HSP90B1@Cytosol
12. BID@Cytoplasm → BID_sub_TRUNC_endsub_*@Cytoplasm