Protein cleaved~BCL2* map

Identifiers
B-cell CLL/lymphoma 2
HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / NECROPTOSIS  map

cleaved~BCL2*@Mitochondrial inner membrane

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / NECROPTOSIS  map

References
rc_re1000( Regulated Cell Death  map ):
influenceDelete: reactants to re
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:10409669
CASP3 mediated cleavage of BCL2 in vitro and in HL60 cells or MCF7 with reconstituted CASP3 expression after exposure to staurosporine
no cleavage by CASP7
PMID:20139069
FKBP8 protects BCL2 from CASP3-mediated degradation
rc_re14( Regulated Cell Death  map ):
PMID:15486085
in FL5.12 cells correlation of BIM-BAX interaction in mitochondrial fractions with presence of unphosphorylated S65 BimEL
non phosphorylatable BimEL: enhanced interaction with BAX and enhanced proapoptotic activity
PMID:12419244
in vitro in reconstituted vesicles, BID induces BAX and membrane permeabilization

Modifications:
In compartment: Mitochondrial inner membrane
  1. cleaved~BCL2*@Mitochondrial inner membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. BCL2|​unk@Mitochondrial inner membrane map → map cleaved~BCL2*@Mitochondrial inner membrane map
    As Catalyser:
    1. BAX|​S163_unk|​T167_unk@Mitochondrial inner membrane map → map rc_s4588