cleaved_BID*

Protein cleaved_BID*

Identifiers
BH3 interacting domain death agonist
HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957

Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / NECROPTOSIS

cleaved_BID*@Cytosol

References
rc_re1620( Regulated Cell Death ):
PMID:9727492
in vitro cleavage of BID by CASP8 and GZMB, BID poor substrate for CASP3
in Jurkat cleavage of BID by CASP8 upon Fas stimulation
in Hela exposed to TNF+CHX cleavage of BID by CASP8
PMID:10805722
in vitro cleavage of in vitro translated BID by purified granzyme B
in Jurkat cells exposed to GZMB+adenovirus, BID cleavage occurs independently of caspases (zVAD-fmk)
PMID:11085743
in Jurkat cells exposed to GZMB+perforin, Bcl2 over-expression mediated cell protection is abrogated by over-over-expression of BID (wt or CASP8-uncleavable mutant) but of D75 (GZMB in vitro cleavage site) mutant
PMID:11085742
in Jurkat cells exposed to GZMB+adenovirus+zVAD-fmk, BID is cleaved and localizes to mitochondria
PMID:10364179
cleavage of BID by CASP8 and CASP3
PMID:11832478
in vitro by CASP2
PMID:18955971
LMP causes the proteolytic activation of Bid (which is cleaved by the two lysosomal cathepsins B and D), which then induces MOMP

cleaved_BID*|myr@Cytosol

References
rc_re515:( Regulated Cell Death ) PMID:11099414

cleaved_BID*|myr@Mitochondrial inner membrane

References
rc_re11( Regulated Cell Death ):
PMID:10950869
direct activation of BAK by tBID
rc_re14( Regulated Cell Death ):
PMID:15486085
in FL5.12 cells correlation of BIM-BAX interaction in mitochondrial fractions with presence of unphosphorylated S65 BimEL
non phosphorylatable BimEL: enhanced interaction with BAX and enhanced proapoptotic activity
PMID:12419244
in vitro in reconstituted vesicles, BID induces BAX and membrane permeabilization
rc_re29( Regulated Cell Death ):
PMID:19968986
cleaved MCL1
PMID:14730312
ASC/PYCARD
PMID:19062087
in vitro in reconstituted liposomes, tBid is sufficient to induce Bax insertion into membrane and oligomerization

Modifications:
In compartment: Cytosol

cleaved_BID*@Cytosol
cleaved_BID*|myr@Cytosol

In compartment: Mitochondrial inner membrane

cleaved_BID*|myr@Mitochondrial inner membrane

Participates in complexes:
In compartment: Mitochondrial inner membrane

Participates in reactions:
As Reactant or Product:

As Catalyser: