Identifiers
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
HUGO:DFFB HGNC:2773 ENTREZ:1677 UNIPROT:O76075
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / NECROPTOSIS
References
synonym:CAD
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / NECROPTOSIS
References
rc_re687( Regulated Cell Death ):
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:9108473
purification of DFFA:DFFB activity from Hela cells cytosol
in vitro, CASP3 mediated of DFFA necessary for nucleosomal DNA fragmentation
in U937 monocyte cells, in Hela cells, in SV589 human fibroblasts, upon staurosporin, DFFA cleaved into the same fragments as in vitro
PMID:9422506
purification and cloning of ICAD:CAD (mouse homologs) from mouse T-cell lymphoma cytosol
CASP3-mediated cleavage of ICAD releases CAD, leading to activation of its enzymatic activity and its nuclear localization
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / NECROPTOSIS
References
rc_re1044( Regulated Cell Death ):
PMID:12198487
by AIFM1
PMID:14716299
in vitro, by AIF+CypA
PMID:11452314
in DFFB KO MEFs by ENDOG
PMID:16818236