Protein GCLC map

Identifiers
glutamate-cysteine ligase, catalytic subunit
HUGO:GCLC HGNC:4311 ENTREZ:2729 UNIPROT:P48506

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / FERROPTOSIS  map
 RECON2  map

References
PMID:27048822
PMID:26653790
PMID:26794443

GCLC@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map

References
rc_re1016:( Regulated Cell Death  map ) from uniprot
rc_re1253( Regulated Cell Death  map ):
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:12000740
in Hela upon TNF+CHX
in Jurkat upon anti FAS

Modifications:
In compartment: Cytosol
  1. GCLC@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. GCLC:​GCLM@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. rGCLC@Nucleus map → map GCLC@Cytosol map
  2. GCLC@Cytosol map + GCLM@Cytosol map → map GCLC:​GCLM@Cytosol map
  3. GCLC@Cytosol map → map cleaved~GCLC*@Cytosol map
As Catalyser:
  1. L-cysteine@Cytosol map + L-glutamate@Cytosol map + ATP@Cytosol map → map L-_gamma_-glutamyl-L-cysteine@Cytosol map + ADP@Cytosol map