Identifiers
baculoviral IAP repeat containing 2
HUGO:BIRC2 hgnc_id:HGNC:590 HGNC:590 ENTREZ:329 UNIPROT:Q13490
HUGO:BIRC2 HGNC:590 ENTREZ:329 UNIPROT:Q13490
HUGO:BIRC2
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / INFLAMMATORY_SIGNALING_PATHWAYS
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / RCD_GENES
Regulated Cell Death / TNF_RESPONSE
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
References
PMID:21232017, PMID:21133840, PMID:17301840
cIAP1 and cIAP2 modify RIP1, TRAF2 and themselves with K63-linked ubiquitin chains. This creates docking sites for the LUBAC complex, an E3 ligase capable of forming linear polyubiquitin chains.
synonym:cIAP1
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / RCD_GENES
Regulated Cell Death / TNF_RESPONSE
References
rc_re708( Regulated Cell Death ):
PMID:15665297
in Hela, cIAP1 is a nuclear protein, that partially translocates to the cytoplasm upon apoptotic stimuli (UV, staurosporin, TRAIL, TNF+CHX), and in a capase-dependent manner
rc_re714( Regulated Cell Death ):
PMID:18082613
in vitro
in 293T, interaction of endogenous of overexpressed cIAP1 and MAD1
in 293T, a RING mutant of cIAP1 does not induce polyubiquitinylation and degradation of MAD1 as the wt does