Protein active~Caspases* map

Identifiers
active BCR-related
HUGO:ABR HGNC:81 ENTREZ:29 UNIPROT:Q12979

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / NECROPTOSIS  map

References
PMID:27558815
used to describe the effect of pan-caspase inhibitors such as z-VAD-fmk
Generic entity
NOTE:all caspases
CASP3
CASP6
CASP7
CASP8
CASP9

active~Caspases*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / NECROPTOSIS  map

References
rc_re709:( Regulated Cell Death  map ) reactionType:is.a
rc_re650( Regulated Cell Death  map ):
in vitro by CASP3, CASP7, CASP8
in Ba/F3 upon IL3 deprivation, in FDCP1 upon IL3 deprivation, in U937 upon serum starvation, z-VAD-fmk inhibitable cleavagePMID:23377657
rc_re651( Regulated Cell Death  map ):
in Ba/F3 upon IL3 deprivation, in FDCP1 upon IL3 deprivation, in U937 upon serum starvation, z-VAD-fmk inhibitable cleavage
in Ba/F3 upon doxorubicin or etoposide or anti-FasPMID:23377657
rc_re708( Regulated Cell Death  map ):
PMID:15665297
in Hela, cIAP1 is a nuclear protein, that partially translocates to the cytoplasm upon apoptotic stimuli (UV, staurosporin, TRAIL, TNF+CHX), and in a capase-dependent manner
rc_re1004( Regulated Cell Death  map ):
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:19171757
in C10 murine alveolar type II epithelial cells
rc_re1152( Regulated Cell Death  map ):
PMID:11399776
in vitro by CASP3 and to a lesser extent by CASP7
PMID:15073321
by LRDD and CRADD
rc_re1242( Regulated Cell Death  map ):
PMID:11287608
in 32D murine cells, upon IL3 withdrawal, BAD cleavage
in vitro cleavage of BAD by recombinant CASP 2,3,7,8,10, and GZMB
rc_re1246( Regulated Cell Death  map ):
influenceDelete: reactants to re
PMID:9435230
rc_re1248:( Regulated Cell Death  map ) PMID:7500007
rc_re1835( Regulated Cell Death  map ):
PMID:23377657
Cleavage of ATG3 by caspases
rc_re1836( Regulated Cell Death  map ):
PMID:19549685
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis.
rc_re1837( Regulated Cell Death  map ):
PMID:22441670
Cleavage of AMBRA1 by Capases

Modifications:
In compartment: Cytosol
  1. active~Caspases*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. active~Caspases*@Cytosol map → map Apoptotic death@Cytosol map
    2. cleaved~Caspase3*@Cytosol map → map active~Caspases*@Cytosol map
    3. cleaved~Caspase7*@Cytosol map → map active~Caspases*@Cytosol map
    4. cleaved~Caspase6*@Cytosol map → map active~Caspases*@Cytosol map
    5. cleaved~Caspase9*@Cytosol map → map active~Caspases*@Cytosol map
    6. cleaved~Caspase8*@Cytosol map → map active~Caspases*@Cytosol map
    As Catalyser:
    1. GLRX@Cytosol map → map cleaved~GLRX*@Cytosol map
    2. Caspase2*@Cytosol map → map cleaved~Caspase2*@Cytosol map
    3. BAD|​unk@Cytosol map → map cleaved~BAD*@Cytosol map
    4. BCL2-XL*@Mitochondrial inner membrane map → map cleaved~BCL2_XL*@Mitochondrial inner membrane map
    5. DNA-PK*@Nucleus map → map cleaved~DNA-PK*@Nucleus map
    6. ATG3@Autopagosome map → map cleaved ATG3*@Autopagosome map
    7. ATG4*@Cytosol map → map Cleaved ATG4D*@Cytosol map
    8. AMBRA1@Cytosol map → map Cleaved AMBRA1@Cytosol map
    9. PIK3C3@Cytosol map → map cleaved~PIK3C3*@Cytosol map
    10. BECN1|​T119_unk@Cytosol map → map cleaved~BECN1*@Cytosol map
    11. BIRC2@Nucleus map → map BIRC2@Cytosol map