Protein RB1 map

Identifiers
RB transcriptional corepressor 1
HUGO:RB1 hgnc_id:HGNC:9884 HGNC:9884 ENTREZ:5925 UNIPROT:P06400
retinoblastoma 1
HUGO:RB1, HGNC:9884, ENTREZ:5925, UNIPROT:P06400

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / G1_CC_PHASE  map
 Cell Cycle DNA Repair  map  / S_CC_PHASE  map
 Cell Cycle DNA Repair  map  / G1_S_CHECKPOINT  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / RCD_GENES  map

References
PMID:24254977
Mouse models have validated the tumour-promoting effects of deleting Rb, Pten or p53 in fibroblasts that converts them from normal fibroblasts to carcinoma associated fibroblasts (CAFs).
PMID:18458534
Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation
PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:7935440

Modifications:
In compartment: Cytosol
  1. RB1@Cytosol map
In compartment: Nucleus
  1. RB1@Nucleus map
  2. RB1|​pho@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. E2F1:​RB1@Nucleus map
  2. E2F1:​RB1|​pho@Nucleus map
  3. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​E2F1:​RB1@Nucleus map
  4. CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho:​RB1@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. RB1@Cytosol map → map NEGATIVE_REGULATORS OF_CAF@Cytosol map
  2. E2F1@Nucleus map + RB1@Nucleus map → map E2F1:​RB1@Nucleus map
  3. E2F1:​RB1@Nucleus map → map E2F1:​RB1|​pho@Nucleus map
  4. E2F1:​RB1|​pho@Nucleus map → map RB1|​pho@Nucleus map + E2F1@Nucleus map
  5. E2F1:​RB1@Nucleus map → map E2F1@Nucleus map + RB1@Nucleus map
  6. RB1|​pho@Nucleus map → map degraded
  7. E2F1:​RB1|​pho@Nucleus map → map E2F1:​RB1@Nucleus map
  8. CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@Nucleus map + RB1@Nucleus map → map CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho:​RB1@Nucleus map
  9. E2F1:​RB1@Nucleus map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@Nucleus map → map BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​E2F1:​RB1@Nucleus map
  10. RB1@Nucleus map → map cleaved_RB1*@Nucleus map
As Catalyser:
  1. G1 phase@Nucleus map → map S phase@Nucleus map
  2. E2F1@Nucleus map → map E2F1@Nucleus map